The teaching materials used by Taiwanese students in class are compiled by different publishers according to the curriculum outline established by the Ministry of Education. However, limited by the layout of teaching materials, it is impossible to incorporate all knowledge referred by the curriculum outline into teaching materials, thus, some are selected and some are abandoned. For example, as the contents can only cover the key points of the general direction, more subtle knowledge could not be incorporated to be used as the expatiation among different key points, due to layout limitations, resulting in relatively weak correlations among the key points. The students who have poor comprehension may not understand the correlations, which thereby affect the students' learning effectiveness. This study suggest that concept maps can be used by teachers as an aid to design teaching material characteristics of more correlation and flexibility. Therefore, this study mainly designs a concept-map-oriented e-book teaching material design system. First, the teachers plan out the concept maps of the teaching materials according to their teaching experience, next, the system connects to the online e-book library, as based on the keywords on the concept maps, to obtain relevant information, then, the teachers select the information to be incorporated into the teaching materials, and finally, the teachers develop the selected information into teaching materials. Thus, the students will be able to read the e-book-format files and obtain the e-book teaching materials through e-book readers. This study divides the students into an experimental group and a control group in order to learn different teaching materials and evaluate the effectiveness of learning, according to test scores after learning, and the questionnaire of system acceptance degree. According to the experimental results, the average test scores of the experimental group are better than those of the control group. In other words, the teaching materials designed with the aid of concept maps can improve students' learning effectiveness.