A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang, M. Vijaya Bhaskar Reddy, Ping Chung Kuo, Chieh Hung Huang, Hung Cheng Shih, E. Jian Lee, Mei Lin Yang, Yann Lii Leu, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume48
DOIs
Publication statusPublished - 2012 Feb

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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