A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang; M. Vijaya Bhaskar Reddy; Ping Chung Kuo; Chieh Hung Huang; Hung Cheng Shih; E. Jian Lee; Mei Lin Yang; Yann Lii Leu; Tian Shung Wu

doi:10.1016/j.ejmech.2011.12.008

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Guan Jhong Huang, M. Vijaya Bhaskar Reddy, Ping Chung Kuo, Chieh Hung Huang, Hung Cheng Shih, E. Jian Lee, Mei Lin Yang, Yann Lii Leu, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

Original language	English
Pages (from-to)	371-378
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	48
DOIs	https://doi.org/10.1016/j.ejmech.2011.12.008
Publication status	Published - 2012 Feb

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery
Organic Chemistry

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Huang, G. J., Bhaskar Reddy, M. V., Kuo, P. C., Huang, C. H., Shih, H. C., Lee, E. J., Yang, M. L., Leu, Y. L., & Wu, T. S. (2012). A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. European Journal of Medicinal Chemistry, 48, 371-378. https://doi.org/10.1016/j.ejmech.2011.12.008

Huang, Guan Jhong ; Bhaskar Reddy, M. Vijaya ; Kuo, Ping Chung ; Huang, Chieh Hung ; Shih, Hung Cheng ; Lee, E. Jian ; Yang, Mei Lin ; Leu, Yann Lii ; Wu, Tian Shung. / A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. In: European Journal of Medicinal Chemistry. 2012 ; Vol. 48. pp. 371-378.

@article{bd1aeacf8e814a2d83fb40bc1663b897,

title = "A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions",

abstract = "In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.",

author = "Huang, {Guan Jhong} and {Bhaskar Reddy}, {M. Vijaya} and Kuo, {Ping Chung} and Huang, {Chieh Hung} and Shih, {Hung Cheng} and Lee, {E. Jian} and Yang, {Mei Lin} and Leu, {Yann Lii} and Wu, {Tian Shung}",

note = "Funding Information: This work was supported by a grant of National Science Council , Taiwan, Republic of China, awarded to T. S. Wu. This study is supported in part by National Cheng Kung University ( HUA100-3-2-232 ). ",

year = "2012",

month = feb,

doi = "10.1016/j.ejmech.2011.12.008",

language = "English",

volume = "48",

pages = "371--378",

journal = "European Journal of Medicinal Chemistry",

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Huang, GJ, Bhaskar Reddy, MV, Kuo, PC, Huang, CH, Shih, HC, Lee, EJ, Yang, ML, Leu, YL & Wu, TS 2012, 'A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions', European Journal of Medicinal Chemistry, vol. 48, pp. 371-378. https://doi.org/10.1016/j.ejmech.2011.12.008

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. / Huang, Guan Jhong; Bhaskar Reddy, M. Vijaya; Kuo, Ping Chung; Huang, Chieh Hung; Shih, Hung Cheng; Lee, E. Jian; Yang, Mei Lin; Leu, Yann Lii; Wu, Tian Shung.

In: European Journal of Medicinal Chemistry, Vol. 48, 02.2012, p. 371-378.

Research output: Contribution to journal › Article › peer-review

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T1 - A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

AU - Huang, Guan Jhong

AU - Bhaskar Reddy, M. Vijaya

AU - Kuo, Ping Chung

AU - Huang, Chieh Hung

AU - Shih, Hung Cheng

AU - Lee, E. Jian

AU - Yang, Mei Lin

AU - Leu, Yann Lii

AU - Wu, Tian Shung

N1 - Funding Information: This work was supported by a grant of National Science Council , Taiwan, Republic of China, awarded to T. S. Wu. This study is supported in part by National Cheng Kung University ( HUA100-3-2-232 ).

PY - 2012/2

Y1 - 2012/2

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AB - In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

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