A developed quantitative measurement using the electro-microchip for Methamphetamine detection

Chia Hsien Yeh, Wei Ting Wang, Yu-Cheng Lin, Pi Lan Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this study, an electro-microchip was successfully used to detect the impedance signals of various Methamphetamine (MET) concentrations based on the developed competitive-immunoassay method. MET is a commonly used drug often abused by drug addicts and can cause irregular behavior; therefore, MET concentration detection is important for quantitative analysis. In this study, the gold nanoparticles (AuNPs) were introduced into an electro-microchip through the specific binding of antibodies, thus constructing a bridge between two electrodes allowing electrons to move between them. When the concentration of the anti-MET antibody-colloidal gold conjugates was diluted 100 times, the detectable limit for MET concentration was 1 ng/mL with 0.5 μg/mL of BSA-MET conjugate. Therefore, the developed electro-microchip is advantageous because it is effective with small sample volumes (30 μL), is a form of rapid quantitative measurement, and works with smaller detectable concentrations than other existing commercial detection products which have the best limit of detection of 100 ng/mL.

Original languageEnglish
Title of host publicationIEEE SENSORS 2012 - Proceedings
DOIs
Publication statusPublished - 2012 Dec 1
Event11th IEEE SENSORS 2012 Conference - Taipei, Taiwan
Duration: 2012 Oct 282012 Oct 31

Publication series

NameProceedings of IEEE Sensors

Other

Other11th IEEE SENSORS 2012 Conference
CountryTaiwan
CityTaipei
Period12-10-2812-10-31

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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  • Cite this

    Yeh, C. H., Wang, W. T., Lin, Y-C., & Shen, P. L. (2012). A developed quantitative measurement using the electro-microchip for Methamphetamine detection. In IEEE SENSORS 2012 - Proceedings [6411406] (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2012.6411406