A Distinct Lung-Interstitium-Resident Memory CD8+ T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection

Pavlo Gilchuk, Timothy M. Hill, Clifford Guy, Sean R. McMaster, Kelli L. Boyd, Whitney A. Rabacal, Pengcheng Lu, Yu Shyr, Jacob E. Kohlmeier, Eric Sebzda, Douglas R. Green, Sebastian Joyce

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The nature and anatomic location of the protective memory CD8+ T cell subset induced by intranasal vaccination remain poorly understood. We developed a vaccination model to assess the anatomic location of protective memory CD8+ T cells and their role in lower airway infections. Memory CD8+ T cells elicited by local intranasal, but not systemic, vaccination with an engineered non-replicative CD8+ T cell-targeted antigen confer enhanced protection to a lethal respiratory viral challenge. This protection depends on a distinct CXCR3LO resident memory CD8+ T (TRM) cell population that preferentially localizes to the pulmonary interstitium. Because they are positioned close to the mucosa, where infection occurs, interstitial TRM cells act before inflammation can recruit circulating memory CD8+ T cells into the lung tissue. This results in a local protective immune response as early as 1 day post-infection. Hence, vaccine strategies that induce lung interstitial TRM cells may confer better protection against respiratory pathogens.

Original languageEnglish
Pages (from-to)1800-1809
Number of pages10
JournalCell Reports
Volume16
Issue number7
DOIs
Publication statusPublished - 2016 Aug 16

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'A Distinct Lung-Interstitium-Resident Memory CD8<sup>+</sup> T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection'. Together they form a unique fingerprint.

Cite this