A fibrinogen assay using specific aptamer on an integrated microfluidic chip

Yi Da Chung, Anirban Sinha, Priya Gopinathan, Hsin Ying Lin, Shu Chu Shiesh, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Fibrinogen is a risk factor and useful biomarker for cardiovascular diseases (CVD). We selected single stranded DNA aptamers as new-affinity reagent which can specifically bind to fibrinogen. An integrated microfluidic chip by using magnetic beads coated with aptamer for detecting fibrinogen was reported. Instead of using antibodies, an aptamer was used as a capturing probe toward fibrinogen. The aptamer has been verified its affinity to fibrinogen. The experimentally data showed that this integrated microfluidic chip can assay fibrinogen concentrations with only few microliter plasma samples.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages1882-1885
Number of pages4
ISBN (Electronic)9781510897571
Publication statusPublished - 2018 Jan 1
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan
Duration: 2018 Nov 112018 Nov 15

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume4

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan
CityKaohsiung
Period18-11-1118-11-15

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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  • Cite this

    Chung, Y. D., Sinha, A., Gopinathan, P., Lin, H. Y., Shiesh, S. C., & Lee, G. B. (2018). A fibrinogen assay using specific aptamer on an integrated microfluidic chip. In 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 (pp. 1882-1885). (22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018; Vol. 4). Chemical and Biological Microsystems Society.