A fully integrated 16-channel closed-loop neural-prosthetic CMOS SoC with wireless power and bidirectional data telemetry for real-time efficient human epileptic seizure control

Cheng Hsiang Cheng, Ping Yuan Tsai, Tzu Yi Yang, Wan Hsueh Cheng, Ting Yang Yen, Zhicong Luo, Xin Hong Qian, Zhi Xin Chen, Tzu Han Lin, Wei Hong Chen, Wei Ming Chen, Sheng-Fu Liang, Fu-Zen Shaw, Cheng Siu Chang, Yue Loong Hsin, Chen Yi Lee, Ming Dou Ker, Chung Yu Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 16-channel closed-loop neuromodulation system-on-chip (SoC) for human epileptic seizure control is proposed and designed. In the proposed SoC, a 16-channel neural-signal acquisition unit (NSAU), a biosignal processor (BSP), a 16-channel high-voltage-tolerant stimulator (HVTS), and wireless power and bidirectional data telemetry are designed. In the NSAU, the input protection circuit is used to prevent MOSFET from overstressing by the high-voltage stimulations. Hence, NSAUs can share electrodes with stimulators. The auto-reset chopper-stabilized capacitive-coupled instrumentation amplifiers (AR-CSCCIAs) are designed with the chopper-stabilized technique with a new offset reduction loop. The measured input-referred noise is 2.09 μ Vrms and the noise-efficiency factor (NEF) is 3.78. The entropy-and-spectrum seizure detection algorithm is implemented in the BSP with 0.76-s seizure detection latency and 97.8% detection accuracy. When the seizure onset is detected by the BSP, the HVTS with adaptive supply control delivers 0.5-3-mA biphasic current stimulation to suppress the seizure onset. The proposed SoC is powered wirelessly, and the bidirectional data telemetry is realized through the same pair of coils in 13.56 MHz. The downlink data rate is 211 Kb/s with the binary phase-shift keying (BPSK) modulation and a new BPSK demodulator. The uplink data rate is 106 Kb/s with the load-shift keying (LSK) modulation. The proposed SoC is fabricated in a 0.18-μm CMOS technology and occupies 25 mm2. Electrical tests have been performed to characterize the SoC performance. In vivo animal experiments using mini-pigs have been performed to successfully verify the closed-loop neuromodulation functions on epileptic seizure suppression.

Original languageEnglish
Article number8463542
Pages (from-to)3314-3326
Number of pages13
JournalIEEE Journal of Solid-State Circuits
Volume53
Issue number11
DOIs
Publication statusPublished - 2018 Nov 1

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Telemetering
Prosthetics
Binary phase shift keying
Electric potential
Modulation
Demodulators
Closed loop systems
Animals
Entropy
System-on-chip
Electrodes
Networks (circuits)
Experiments

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

Cheng, Cheng Hsiang ; Tsai, Ping Yuan ; Yang, Tzu Yi ; Cheng, Wan Hsueh ; Yen, Ting Yang ; Luo, Zhicong ; Qian, Xin Hong ; Chen, Zhi Xin ; Lin, Tzu Han ; Chen, Wei Hong ; Chen, Wei Ming ; Liang, Sheng-Fu ; Shaw, Fu-Zen ; Chang, Cheng Siu ; Hsin, Yue Loong ; Lee, Chen Yi ; Ker, Ming Dou ; Wu, Chung Yu. / A fully integrated 16-channel closed-loop neural-prosthetic CMOS SoC with wireless power and bidirectional data telemetry for real-time efficient human epileptic seizure control. In: IEEE Journal of Solid-State Circuits. 2018 ; Vol. 53, No. 11. pp. 3314-3326.
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abstract = "A 16-channel closed-loop neuromodulation system-on-chip (SoC) for human epileptic seizure control is proposed and designed. In the proposed SoC, a 16-channel neural-signal acquisition unit (NSAU), a biosignal processor (BSP), a 16-channel high-voltage-tolerant stimulator (HVTS), and wireless power and bidirectional data telemetry are designed. In the NSAU, the input protection circuit is used to prevent MOSFET from overstressing by the high-voltage stimulations. Hence, NSAUs can share electrodes with stimulators. The auto-reset chopper-stabilized capacitive-coupled instrumentation amplifiers (AR-CSCCIAs) are designed with the chopper-stabilized technique with a new offset reduction loop. The measured input-referred noise is 2.09 μ Vrms and the noise-efficiency factor (NEF) is 3.78. The entropy-and-spectrum seizure detection algorithm is implemented in the BSP with 0.76-s seizure detection latency and 97.8{\%} detection accuracy. When the seizure onset is detected by the BSP, the HVTS with adaptive supply control delivers 0.5-3-mA biphasic current stimulation to suppress the seizure onset. The proposed SoC is powered wirelessly, and the bidirectional data telemetry is realized through the same pair of coils in 13.56 MHz. The downlink data rate is 211 Kb/s with the binary phase-shift keying (BPSK) modulation and a new BPSK demodulator. The uplink data rate is 106 Kb/s with the load-shift keying (LSK) modulation. The proposed SoC is fabricated in a 0.18-μm CMOS technology and occupies 25 mm2. Electrical tests have been performed to characterize the SoC performance. In vivo animal experiments using mini-pigs have been performed to successfully verify the closed-loop neuromodulation functions on epileptic seizure suppression.",
author = "Cheng, {Cheng Hsiang} and Tsai, {Ping Yuan} and Yang, {Tzu Yi} and Cheng, {Wan Hsueh} and Yen, {Ting Yang} and Zhicong Luo and Qian, {Xin Hong} and Chen, {Zhi Xin} and Lin, {Tzu Han} and Chen, {Wei Hong} and Chen, {Wei Ming} and Sheng-Fu Liang and Fu-Zen Shaw and Chang, {Cheng Siu} and Hsin, {Yue Loong} and Lee, {Chen Yi} and Ker, {Ming Dou} and Wu, {Chung Yu}",
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Cheng, CH, Tsai, PY, Yang, TY, Cheng, WH, Yen, TY, Luo, Z, Qian, XH, Chen, ZX, Lin, TH, Chen, WH, Chen, WM, Liang, S-F, Shaw, F-Z, Chang, CS, Hsin, YL, Lee, CY, Ker, MD & Wu, CY 2018, 'A fully integrated 16-channel closed-loop neural-prosthetic CMOS SoC with wireless power and bidirectional data telemetry for real-time efficient human epileptic seizure control', IEEE Journal of Solid-State Circuits, vol. 53, no. 11, 8463542, pp. 3314-3326. https://doi.org/10.1109/JSSC.2018.2867293

A fully integrated 16-channel closed-loop neural-prosthetic CMOS SoC with wireless power and bidirectional data telemetry for real-time efficient human epileptic seizure control. / Cheng, Cheng Hsiang; Tsai, Ping Yuan; Yang, Tzu Yi; Cheng, Wan Hsueh; Yen, Ting Yang; Luo, Zhicong; Qian, Xin Hong; Chen, Zhi Xin; Lin, Tzu Han; Chen, Wei Hong; Chen, Wei Ming; Liang, Sheng-Fu; Shaw, Fu-Zen; Chang, Cheng Siu; Hsin, Yue Loong; Lee, Chen Yi; Ker, Ming Dou; Wu, Chung Yu.

In: IEEE Journal of Solid-State Circuits, Vol. 53, No. 11, 8463542, 01.11.2018, p. 3314-3326.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A fully integrated 16-channel closed-loop neural-prosthetic CMOS SoC with wireless power and bidirectional data telemetry for real-time efficient human epileptic seizure control

AU - Cheng, Cheng Hsiang

AU - Tsai, Ping Yuan

AU - Yang, Tzu Yi

AU - Cheng, Wan Hsueh

AU - Yen, Ting Yang

AU - Luo, Zhicong

AU - Qian, Xin Hong

AU - Chen, Zhi Xin

AU - Lin, Tzu Han

AU - Chen, Wei Hong

AU - Chen, Wei Ming

AU - Liang, Sheng-Fu

AU - Shaw, Fu-Zen

AU - Chang, Cheng Siu

AU - Hsin, Yue Loong

AU - Lee, Chen Yi

AU - Ker, Ming Dou

AU - Wu, Chung Yu

PY - 2018/11/1

Y1 - 2018/11/1

N2 - A 16-channel closed-loop neuromodulation system-on-chip (SoC) for human epileptic seizure control is proposed and designed. In the proposed SoC, a 16-channel neural-signal acquisition unit (NSAU), a biosignal processor (BSP), a 16-channel high-voltage-tolerant stimulator (HVTS), and wireless power and bidirectional data telemetry are designed. In the NSAU, the input protection circuit is used to prevent MOSFET from overstressing by the high-voltage stimulations. Hence, NSAUs can share electrodes with stimulators. The auto-reset chopper-stabilized capacitive-coupled instrumentation amplifiers (AR-CSCCIAs) are designed with the chopper-stabilized technique with a new offset reduction loop. The measured input-referred noise is 2.09 μ Vrms and the noise-efficiency factor (NEF) is 3.78. The entropy-and-spectrum seizure detection algorithm is implemented in the BSP with 0.76-s seizure detection latency and 97.8% detection accuracy. When the seizure onset is detected by the BSP, the HVTS with adaptive supply control delivers 0.5-3-mA biphasic current stimulation to suppress the seizure onset. The proposed SoC is powered wirelessly, and the bidirectional data telemetry is realized through the same pair of coils in 13.56 MHz. The downlink data rate is 211 Kb/s with the binary phase-shift keying (BPSK) modulation and a new BPSK demodulator. The uplink data rate is 106 Kb/s with the load-shift keying (LSK) modulation. The proposed SoC is fabricated in a 0.18-μm CMOS technology and occupies 25 mm2. Electrical tests have been performed to characterize the SoC performance. In vivo animal experiments using mini-pigs have been performed to successfully verify the closed-loop neuromodulation functions on epileptic seizure suppression.

AB - A 16-channel closed-loop neuromodulation system-on-chip (SoC) for human epileptic seizure control is proposed and designed. In the proposed SoC, a 16-channel neural-signal acquisition unit (NSAU), a biosignal processor (BSP), a 16-channel high-voltage-tolerant stimulator (HVTS), and wireless power and bidirectional data telemetry are designed. In the NSAU, the input protection circuit is used to prevent MOSFET from overstressing by the high-voltage stimulations. Hence, NSAUs can share electrodes with stimulators. The auto-reset chopper-stabilized capacitive-coupled instrumentation amplifiers (AR-CSCCIAs) are designed with the chopper-stabilized technique with a new offset reduction loop. The measured input-referred noise is 2.09 μ Vrms and the noise-efficiency factor (NEF) is 3.78. The entropy-and-spectrum seizure detection algorithm is implemented in the BSP with 0.76-s seizure detection latency and 97.8% detection accuracy. When the seizure onset is detected by the BSP, the HVTS with adaptive supply control delivers 0.5-3-mA biphasic current stimulation to suppress the seizure onset. The proposed SoC is powered wirelessly, and the bidirectional data telemetry is realized through the same pair of coils in 13.56 MHz. The downlink data rate is 211 Kb/s with the binary phase-shift keying (BPSK) modulation and a new BPSK demodulator. The uplink data rate is 106 Kb/s with the load-shift keying (LSK) modulation. The proposed SoC is fabricated in a 0.18-μm CMOS technology and occupies 25 mm2. Electrical tests have been performed to characterize the SoC performance. In vivo animal experiments using mini-pigs have been performed to successfully verify the closed-loop neuromodulation functions on epileptic seizure suppression.

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