Abstract
This paper presents a fully functionally integrated 1024-channel mixed-mode and mixed-voltage system-on-a-chip (SoC) for epi-retinal and neural prostheses. Taking an AC input, an integrated power telemetry circuits is capable of generating multiple DC voltages with a voltage conversion efficiency of 83% at a load of 100 mW without external diodes or separate power integrated circuits, reducing the form factor of the prosthetic device. A wireless DPSK receiver with a novel noise reduction scheme supports a data rate of 2 Mb/s at a bit-error-rate of 2\,× 10 -7. The 1024-channel stimulator array meets an output compliance voltage of 10~V and provides flexible stimulation waveforms. Through chip-clustering, the stimulator array can be further expanded to 4096 channels. This SoC is designed and fabricated in TSMC 0.18 μm high-voltage 32 V CMOS process and occupies a chip area of 5.7 mm\,×, 6.6 mm. Using this SoC, a retinal implant bench-top test system is set up with real-time visual verification. In-vitro experiment conducted in artificial vitreous humor is designed and set-up to investigate stimulation waveforms for better visual resolution. In our in-vivo experiment, a hind-limb paralyzed rat with spinal cord transection and implanted chronic epidural electrodes has been shown to regain stepping and standing abilities using stimulus provided by the SoC.
Original language | English |
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Article number | 6716090 |
Pages (from-to) | 761-772 |
Number of pages | 12 |
Journal | IEEE transactions on biomedical circuits and systems |
Volume | 7 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2013 Dec |
All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Electrical and Electronic Engineering