TY - JOUR
T1 - A Fully Integrated Wireless SoC for Motor Function Recovery after Spinal Cord Injury
AU - Lo, Yi Kai
AU - Kuan, Yen Cheng
AU - Culaclii, Stanislav
AU - Kim, Brian
AU - Wang, Po Min
AU - Chang, Chih Wei
AU - Massachi, Jonathan A.
AU - Zhu, Minji
AU - Chen, Kuanfu
AU - Gad, Parag
AU - Edgerton, V. Reggie
AU - Liu, Wentai
N1 - Publisher Copyright:
© 2007-2012 IEEE.
PY - 2017/6
Y1 - 2017/6
N2 - This paper presents a wirelessly powered, fully integrated system-on-a-chip (SoC) supporting 160-channel stimulation, 16-channel recording, and 48-channel bio-impedance characterization to enable partial motor function recovery through epidural spinal cord electrical stimulation. A wireless transceiver is designed to support quasi full-duplex data telemetry at a data rate of 2 Mb/s. Furthermore, a unique in situ bio-impedance characterization scheme based on time-domain analysis is implemented to derive the Randles cell electrode model of the electrode-electrolyte interface. The SoC supports concurrent stimulation and recording while the high-density stimulator array meets an output compliance voltage of up to ±10 V with versatile stimulus programmability. The SoC consumes 18 mW and occupies a chip area of 5.7 mm × 4.4 mm using 0.18 μm high-voltage CMOS process. In our in vivo rodent experiment, the SoC is used to perform wireless recording of EMG responses while stimulation is applied to enable the standing and stepping of a paralyzed rat. To facilitate the system integration, a novel thin film polymer packaging technique is developed to provide a heterogeneous integration of the SoC, coils, discrete components, and high-density flexible electrode array, resulting in a miniaturized prototype implant with a weight and form factor of 0.7 g and 0.5 cm3, respectively.
AB - This paper presents a wirelessly powered, fully integrated system-on-a-chip (SoC) supporting 160-channel stimulation, 16-channel recording, and 48-channel bio-impedance characterization to enable partial motor function recovery through epidural spinal cord electrical stimulation. A wireless transceiver is designed to support quasi full-duplex data telemetry at a data rate of 2 Mb/s. Furthermore, a unique in situ bio-impedance characterization scheme based on time-domain analysis is implemented to derive the Randles cell electrode model of the electrode-electrolyte interface. The SoC supports concurrent stimulation and recording while the high-density stimulator array meets an output compliance voltage of up to ±10 V with versatile stimulus programmability. The SoC consumes 18 mW and occupies a chip area of 5.7 mm × 4.4 mm using 0.18 μm high-voltage CMOS process. In our in vivo rodent experiment, the SoC is used to perform wireless recording of EMG responses while stimulation is applied to enable the standing and stepping of a paralyzed rat. To facilitate the system integration, a novel thin film polymer packaging technique is developed to provide a heterogeneous integration of the SoC, coils, discrete components, and high-density flexible electrode array, resulting in a miniaturized prototype implant with a weight and form factor of 0.7 g and 0.5 cm3, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85018877051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018877051&partnerID=8YFLogxK
U2 - 10.1109/TBCAS.2017.2679441
DO - 10.1109/TBCAS.2017.2679441
M3 - Article
AN - SCOPUS:85018877051
SN - 1932-4545
VL - 11
SP - 497
EP - 509
JO - IEEE transactions on biomedical circuits and systems
JF - IEEE transactions on biomedical circuits and systems
IS - 3
M1 - 7920366
ER -