A microfluidic device for generation of spatial and temporal logarithmic concentration

Chang Yu Chen, Ting-Yuan Tu, De Shien Jong, Andrew M. Wo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents generation of either statically spatial or dynamically temporal logarithmic concentration in the same microfluidic device. We propose a serial dilution principle by controlling the flow pattern at each branching point via designing the flow resistance of microchannels. Simple and linear ratio of the flow resistance results in desired logarithmic concentration at outlets. Dynamically controllable logarithmic concentration is feasible as well by integrating valves in the microfluidic device. Applications include fast dose-response experiments and cellular analysis under rapid change of logarithmic concentration.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1037-1039
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009 Jan 1
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09-11-0109-11-05

Fingerprint

Microfluidics
Microchannels
Flow patterns
Dilution
Experiments

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Chen, C. Y., Tu, T-Y., Jong, D. S., & Wo, A. M. (2009). A microfluidic device for generation of spatial and temporal logarithmic concentration. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1037-1039). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.
Chen, Chang Yu ; Tu, Ting-Yuan ; Jong, De Shien ; Wo, Andrew M. / A microfluidic device for generation of spatial and temporal logarithmic concentration. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. pp. 1037-1039 (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences).
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Chen, CY, Tu, T-Y, Jong, DS & Wo, AM 2009, A microfluidic device for generation of spatial and temporal logarithmic concentration. in Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 1037-1039, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, Korea, Republic of, 09-11-01.

A microfluidic device for generation of spatial and temporal logarithmic concentration. / Chen, Chang Yu; Tu, Ting-Yuan; Jong, De Shien; Wo, Andrew M.

Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. p. 1037-1039 (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - This paper presents generation of either statically spatial or dynamically temporal logarithmic concentration in the same microfluidic device. We propose a serial dilution principle by controlling the flow pattern at each branching point via designing the flow resistance of microchannels. Simple and linear ratio of the flow resistance results in desired logarithmic concentration at outlets. Dynamically controllable logarithmic concentration is feasible as well by integrating valves in the microfluidic device. Applications include fast dose-response experiments and cellular analysis under rapid change of logarithmic concentration.

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M3 - Conference contribution

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Chen CY, Tu T-Y, Jong DS, Wo AM. A microfluidic device for generation of spatial and temporal logarithmic concentration. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2009. p. 1037-1039. (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences).