A micromachine-based flow cytometer chip integrated with micro-pumps/valves for multi-wavelength detection applications

C. M. Chang, S. K. Hsiung, G. B. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

This study presents a new micromachine-based cell counting and sorting system capable of multi-wavelength detection for biological applications. Chip-based flow cytometers have been extensively investigated recently. Several unique features have been integrated on this new cell-analysis system. First, a series of new serpentine-shape pneumatic micro-pumps were used to drive sample and sheath flows and generate a hydrodynamic focusing effect. The control of fluids could be achieved with ease by using this approach. Multiple embedded optical fibers were then used to transmit the light source and collect induced fluorescence signals in and out of the chip device. Cells labeled with different fluorescent dyes could be then individually detected by corresponding fibers using lasers with different wavelengths. Finally, three pneumatic micro-valves downstream were used for cell sorting. The developed micro flow cytometer could be used for fast analysis of cell-related bio-medical applications.

Original languageEnglish
Title of host publicationProgress on Advanced Manufacture for Micro/Nano Technology 2005 - Proceedings of the 2005 International Conference on Advanced Manufacture
PublisherTrans Tech Publications Ltd
Pages637-642
Number of pages6
EditionPART 1
ISBN (Print)0878499903, 9780878499908
DOIs
Publication statusPublished - 2006
Event2005 International Conference on Advanced Manufacture, ICAM2005 - Taipei, R.O.C., Taiwan
Duration: 2005 Nov 282005 Dec 2

Publication series

NameMaterials Science Forum
NumberPART 1
Volume505-507
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Other

Other2005 International Conference on Advanced Manufacture, ICAM2005
Country/TerritoryTaiwan
CityTaipei, R.O.C.
Period05-11-2805-12-02

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Fingerprint

Dive into the research topics of 'A micromachine-based flow cytometer chip integrated with micro-pumps/valves for multi-wavelength detection applications'. Together they form a unique fingerprint.

Cite this