Abstract
Objective: Establish a possible conceptual relationship among Apo E and PLA2 polymorphism and lipid profiles. Methods: Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E and PLA2 polymorphisms and lipid profiles. Two hundred fifty-six participants agreed to have venous blood drawn for DNA studies. Results: By multiple linear regression, the PLA2 A2 allele showed a statistically significant influence on LDL-C (p = 0.0097), and the Apoε2 allele showed a statistically significant influence on HDL-C (p = 0.0004), however, the interaction between the PLA2 A2 allele and the Apoε2 allele was found to be significant in the blood fraction of HDL-C (p = 0.0388) and LDL-C (p = 0.0002). Decreasing HDL-C and increasing LDL-C were found when the PLA2 A2 and Apoε2 allele co-existed. Conclusion: The presence of a physiologic balance contributes significantly to homeostatic and compensatory responses regulating blood HDL-C and LDL-C profiles. A module map of the generation-control cycle and conditional activity among Apo E, PLA2, and lipid levels is presented, and both behaviours and biological perspectives under the consilience model may suggest a new approach to many kinds of complex disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 135-144 |
| Number of pages | 10 |
| Journal | Human Heredity |
| Volume | 62 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2006 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
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A module map showing interaction between apolipoprotein E and phospholipase A2 polymorphism in lipid profiles. / Lung, For Wey; Kao, Wei Tsung; Shu, Bih-Ching; Yen, Yung Chieh; Tzeng, Dong Sheng.
In: Human Heredity, Vol. 62, No. 3, 01.11.2006, p. 135-144.Research output: Contribution to journal › Article
TY - JOUR
T1 - A module map showing interaction between apolipoprotein E and phospholipase A2 polymorphism in lipid profiles
AU - Lung, For Wey
AU - Kao, Wei Tsung
AU - Shu, Bih-Ching
AU - Yen, Yung Chieh
AU - Tzeng, Dong Sheng
PY - 2006/11/1
Y1 - 2006/11/1
N2 - Objective: Establish a possible conceptual relationship among Apo E and PLA2 polymorphism and lipid profiles. Methods: Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E and PLA2 polymorphisms and lipid profiles. Two hundred fifty-six participants agreed to have venous blood drawn for DNA studies. Results: By multiple linear regression, the PLA2 A2 allele showed a statistically significant influence on LDL-C (p = 0.0097), and the Apoε2 allele showed a statistically significant influence on HDL-C (p = 0.0004), however, the interaction between the PLA2 A2 allele and the Apoε2 allele was found to be significant in the blood fraction of HDL-C (p = 0.0388) and LDL-C (p = 0.0002). Decreasing HDL-C and increasing LDL-C were found when the PLA2 A2 and Apoε2 allele co-existed. Conclusion: The presence of a physiologic balance contributes significantly to homeostatic and compensatory responses regulating blood HDL-C and LDL-C profiles. A module map of the generation-control cycle and conditional activity among Apo E, PLA2, and lipid levels is presented, and both behaviours and biological perspectives under the consilience model may suggest a new approach to many kinds of complex disorders.
AB - Objective: Establish a possible conceptual relationship among Apo E and PLA2 polymorphism and lipid profiles. Methods: Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E and PLA2 polymorphisms and lipid profiles. Two hundred fifty-six participants agreed to have venous blood drawn for DNA studies. Results: By multiple linear regression, the PLA2 A2 allele showed a statistically significant influence on LDL-C (p = 0.0097), and the Apoε2 allele showed a statistically significant influence on HDL-C (p = 0.0004), however, the interaction between the PLA2 A2 allele and the Apoε2 allele was found to be significant in the blood fraction of HDL-C (p = 0.0388) and LDL-C (p = 0.0002). Decreasing HDL-C and increasing LDL-C were found when the PLA2 A2 and Apoε2 allele co-existed. Conclusion: The presence of a physiologic balance contributes significantly to homeostatic and compensatory responses regulating blood HDL-C and LDL-C profiles. A module map of the generation-control cycle and conditional activity among Apo E, PLA2, and lipid levels is presented, and both behaviours and biological perspectives under the consilience model may suggest a new approach to many kinds of complex disorders.
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U2 - 10.1159/000096417
DO - 10.1159/000096417
M3 - Article
VL - 62
SP - 135
EP - 144
JO - Human Heredity
JF - Human Heredity
SN - 0001-5652
IS - 3
ER -