A module map showing interaction between apolipoprotein E and phospholipase A2 polymorphism in lipid profiles

For Wey Lung, Wei Tsung Kao, Bih Ching Shu, Yung Chieh Yen, Dong Sheng Tzeng

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective: Establish a possible conceptual relationship among Apo E and PLA2 polymorphism and lipid profiles. Methods: Five hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E and PLA2 polymorphisms and lipid profiles. Two hundred fifty-six participants agreed to have venous blood drawn for DNA studies. Results: By multiple linear regression, the PLA2 A2 allele showed a statistically significant influence on LDL-C (p = 0.0097), and the Apoε2 allele showed a statistically significant influence on HDL-C (p = 0.0004), however, the interaction between the PLA2 A2 allele and the Apoε2 allele was found to be significant in the blood fraction of HDL-C (p = 0.0388) and LDL-C (p = 0.0002). Decreasing HDL-C and increasing LDL-C were found when the PLA2 A2 and Apoε2 allele co-existed. Conclusion: The presence of a physiologic balance contributes significantly to homeostatic and compensatory responses regulating blood HDL-C and LDL-C profiles. A module map of the generation-control cycle and conditional activity among Apo E, PLA2, and lipid levels is presented, and both behaviours and biological perspectives under the consilience model may suggest a new approach to many kinds of complex disorders.

Original languageEnglish
Pages (from-to)135-144
Number of pages10
JournalHuman Heredity
Volume62
Issue number3
DOIs
Publication statusPublished - 2006 Nov 1

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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