A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan

prevalence, determinants, and impact on quality of life

Wen Chi Chou, Jen Shi Chen, Chia Yen Hung, Chang Hsien Lu, Yu Yun Shao, Tzeon Jye Chiou, Yung Chuan Sung, Kun Ming Rau, Chia-Jui Yen, Su Peng Yeh, Ta Chih Liu, Ming Fang Wu, Ming Yang Lee, Ming Sun Yu, Wen Li Hwang, Pang Yu Lai, Cheng Shyong Chang, Ruey Kuen Hsieh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Poor adherence to analgesic drugs is one of the most common barriers to adequate pain management. This prospective, cross-sectional, patient-oriented observational study aimed to explore the adherence rate, clinical factors, and impact of adherence to analgesic drugs on the quality of life (QoL) among cancer outpatients in Taiwan. Methods: Eight hundred ninety-seven consecutive adult outpatients with cancer who had reported tumor pain and received regular analgesic drug treatment were enrolled from 16 medical centers across Taiwan. The Brief Pain Inventory was used to assess pain intensity and QoL. Morisky’s four-item medication adherence scale was used to assess adherence to analgesic drugs. Clinical factors possibly associated with good adherence to analgesic drugs were analyzed using multivariate logistic regression analyses. Results: Of the 897 patients, 26.9% met criteria for the good, 35.5% for the moderate, and 37.6% for the poor adherence groups. The good adherence group had significantly better QoL outcomes than the moderate and poor adherence groups (all p < 0.05). Age ≥ 50 years, head and neck or hematological malignancies, cancer-related pain, patients who agreed or strongly agreed that the side effects of analgesic drugs were tolerable, and patients who disagreed or strongly disagreed that the dosing schedule could be flexibly self-adjusted to deal with the actual pain were predictors of good adherence to analgesic drugs. Conclusions: Awareness of the clinical factors associated with adherence to analgesic drugs may help clinicians to identify cancer patients at a greater risk of non-adherence, reinforce optimal pain management, and improve the QoL by enhancing adherence to pain medications.

Original languageEnglish
Pages (from-to)2857-2867
Number of pages11
JournalSupportive Care in Cancer
Volume27
Issue number8
DOIs
Publication statusPublished - 2019 Aug 1

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Taiwan
Analgesics
Quality of Life
Neoplasms
Pain
Pain Management
Outpatients
Medication Adherence
Surveys and Questionnaires
Hematologic Neoplasms
Drug-Related Side Effects and Adverse Reactions
Observational Studies
Appointments and Schedules
Neck
Logistic Models
Head
Regression Analysis
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Chou, Wen Chi ; Chen, Jen Shi ; Hung, Chia Yen ; Lu, Chang Hsien ; Shao, Yu Yun ; Chiou, Tzeon Jye ; Sung, Yung Chuan ; Rau, Kun Ming ; Yen, Chia-Jui ; Yeh, Su Peng ; Liu, Ta Chih ; Wu, Ming Fang ; Lee, Ming Yang ; Yu, Ming Sun ; Hwang, Wen Li ; Lai, Pang Yu ; Chang, Cheng Shyong ; Hsieh, Ruey Kuen. / A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan : prevalence, determinants, and impact on quality of life. In: Supportive Care in Cancer. 2019 ; Vol. 27, No. 8. pp. 2857-2867.
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title = "A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life",
abstract = "Purpose: Poor adherence to analgesic drugs is one of the most common barriers to adequate pain management. This prospective, cross-sectional, patient-oriented observational study aimed to explore the adherence rate, clinical factors, and impact of adherence to analgesic drugs on the quality of life (QoL) among cancer outpatients in Taiwan. Methods: Eight hundred ninety-seven consecutive adult outpatients with cancer who had reported tumor pain and received regular analgesic drug treatment were enrolled from 16 medical centers across Taiwan. The Brief Pain Inventory was used to assess pain intensity and QoL. Morisky’s four-item medication adherence scale was used to assess adherence to analgesic drugs. Clinical factors possibly associated with good adherence to analgesic drugs were analyzed using multivariate logistic regression analyses. Results: Of the 897 patients, 26.9{\%} met criteria for the good, 35.5{\%} for the moderate, and 37.6{\%} for the poor adherence groups. The good adherence group had significantly better QoL outcomes than the moderate and poor adherence groups (all p < 0.05). Age ≥ 50 years, head and neck or hematological malignancies, cancer-related pain, patients who agreed or strongly agreed that the side effects of analgesic drugs were tolerable, and patients who disagreed or strongly disagreed that the dosing schedule could be flexibly self-adjusted to deal with the actual pain were predictors of good adherence to analgesic drugs. Conclusions: Awareness of the clinical factors associated with adherence to analgesic drugs may help clinicians to identify cancer patients at a greater risk of non-adherence, reinforce optimal pain management, and improve the QoL by enhancing adherence to pain medications.",
author = "Chou, {Wen Chi} and Chen, {Jen Shi} and Hung, {Chia Yen} and Lu, {Chang Hsien} and Shao, {Yu Yun} and Chiou, {Tzeon Jye} and Sung, {Yung Chuan} and Rau, {Kun Ming} and Chia-Jui Yen and Yeh, {Su Peng} and Liu, {Ta Chih} and Wu, {Ming Fang} and Lee, {Ming Yang} and Yu, {Ming Sun} and Hwang, {Wen Li} and Lai, {Pang Yu} and Chang, {Cheng Shyong} and Hsieh, {Ruey Kuen}",
year = "2019",
month = "8",
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Chou, WC, Chen, JS, Hung, CY, Lu, CH, Shao, YY, Chiou, TJ, Sung, YC, Rau, KM, Yen, C-J, Yeh, SP, Liu, TC, Wu, MF, Lee, MY, Yu, MS, Hwang, WL, Lai, PY, Chang, CS & Hsieh, RK 2019, 'A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan: prevalence, determinants, and impact on quality of life', Supportive Care in Cancer, vol. 27, no. 8, pp. 2857-2867. https://doi.org/10.1007/s00520-018-4599-x

A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan : prevalence, determinants, and impact on quality of life. / Chou, Wen Chi; Chen, Jen Shi; Hung, Chia Yen; Lu, Chang Hsien; Shao, Yu Yun; Chiou, Tzeon Jye; Sung, Yung Chuan; Rau, Kun Ming; Yen, Chia-Jui; Yeh, Su Peng; Liu, Ta Chih; Wu, Ming Fang; Lee, Ming Yang; Yu, Ming Sun; Hwang, Wen Li; Lai, Pang Yu; Chang, Cheng Shyong; Hsieh, Ruey Kuen.

In: Supportive Care in Cancer, Vol. 27, No. 8, 01.08.2019, p. 2857-2867.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A nationwide survey of adherence to analgesic drugs among cancer patients in Taiwan

T2 - prevalence, determinants, and impact on quality of life

AU - Chou, Wen Chi

AU - Chen, Jen Shi

AU - Hung, Chia Yen

AU - Lu, Chang Hsien

AU - Shao, Yu Yun

AU - Chiou, Tzeon Jye

AU - Sung, Yung Chuan

AU - Rau, Kun Ming

AU - Yen, Chia-Jui

AU - Yeh, Su Peng

AU - Liu, Ta Chih

AU - Wu, Ming Fang

AU - Lee, Ming Yang

AU - Yu, Ming Sun

AU - Hwang, Wen Li

AU - Lai, Pang Yu

AU - Chang, Cheng Shyong

AU - Hsieh, Ruey Kuen

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Purpose: Poor adherence to analgesic drugs is one of the most common barriers to adequate pain management. This prospective, cross-sectional, patient-oriented observational study aimed to explore the adherence rate, clinical factors, and impact of adherence to analgesic drugs on the quality of life (QoL) among cancer outpatients in Taiwan. Methods: Eight hundred ninety-seven consecutive adult outpatients with cancer who had reported tumor pain and received regular analgesic drug treatment were enrolled from 16 medical centers across Taiwan. The Brief Pain Inventory was used to assess pain intensity and QoL. Morisky’s four-item medication adherence scale was used to assess adherence to analgesic drugs. Clinical factors possibly associated with good adherence to analgesic drugs were analyzed using multivariate logistic regression analyses. Results: Of the 897 patients, 26.9% met criteria for the good, 35.5% for the moderate, and 37.6% for the poor adherence groups. The good adherence group had significantly better QoL outcomes than the moderate and poor adherence groups (all p < 0.05). Age ≥ 50 years, head and neck or hematological malignancies, cancer-related pain, patients who agreed or strongly agreed that the side effects of analgesic drugs were tolerable, and patients who disagreed or strongly disagreed that the dosing schedule could be flexibly self-adjusted to deal with the actual pain were predictors of good adherence to analgesic drugs. Conclusions: Awareness of the clinical factors associated with adherence to analgesic drugs may help clinicians to identify cancer patients at a greater risk of non-adherence, reinforce optimal pain management, and improve the QoL by enhancing adherence to pain medications.

AB - Purpose: Poor adherence to analgesic drugs is one of the most common barriers to adequate pain management. This prospective, cross-sectional, patient-oriented observational study aimed to explore the adherence rate, clinical factors, and impact of adherence to analgesic drugs on the quality of life (QoL) among cancer outpatients in Taiwan. Methods: Eight hundred ninety-seven consecutive adult outpatients with cancer who had reported tumor pain and received regular analgesic drug treatment were enrolled from 16 medical centers across Taiwan. The Brief Pain Inventory was used to assess pain intensity and QoL. Morisky’s four-item medication adherence scale was used to assess adherence to analgesic drugs. Clinical factors possibly associated with good adherence to analgesic drugs were analyzed using multivariate logistic regression analyses. Results: Of the 897 patients, 26.9% met criteria for the good, 35.5% for the moderate, and 37.6% for the poor adherence groups. The good adherence group had significantly better QoL outcomes than the moderate and poor adherence groups (all p < 0.05). Age ≥ 50 years, head and neck or hematological malignancies, cancer-related pain, patients who agreed or strongly agreed that the side effects of analgesic drugs were tolerable, and patients who disagreed or strongly disagreed that the dosing schedule could be flexibly self-adjusted to deal with the actual pain were predictors of good adherence to analgesic drugs. Conclusions: Awareness of the clinical factors associated with adherence to analgesic drugs may help clinicians to identify cancer patients at a greater risk of non-adherence, reinforce optimal pain management, and improve the QoL by enhancing adherence to pain medications.

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DO - 10.1007/s00520-018-4599-x

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VL - 27

SP - 2857

EP - 2867

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 8

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