A new dimeric phenylpropanoid and cytotoxic norditerpene constituents from Podocarpus nakaii

Syh Yuan Huang, Long Yun Fan, Ya Ching Shen, Chia Ching Liao, Li Chuan Hsu, Ya Wen Hsu, Tian Shan Wu, Ping Chun Hsiao, Chien Chang Shen, Ming Jaw Don, Yao Haur Kuo

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5 Citations (Scopus)

Abstract

A new dimeric phenylpropanoid namely podonaka A (1), along with the 13 known compounds including diterpenes (2 and 3), norditerpenes (4 and 5), benzenoids (6-10), steroids (11 and 12), chalcone (13), and megastigmane (14), was isolated from the EtOH extract of Podocarpus nakaii Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR and MS techniques. Biological evaluation showed that norditerpenes, inumakilactone B (4), and podolactone E (5) have potent cytotoxic activities against Daoy, WiDr, KB, and HeLa tumor cell lines. Moreover, low dosage of 5 may induce early apoptosis in KB cells before 12h.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
JournalJournal of Asian Natural Products Research
Volume11
Issue number5
DOIs
Publication statusPublished - 2009 May

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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