A new dimeric phenylpropanoid and cytotoxic norditerpene constituents from Podocarpus nakaii

Syh Yuan Huang; Long Yun Fan; Ya Ching Shen; Chia Ching Liao; Li Chuan Hsu; Ya Wen Hsu; Tian Shan Wu; Ping Chun Hsiao; Chien Chang Shen; Ming Jaw Don; Yao Haur Kuo

doi:10.1080/10286020902877739

A new dimeric phenylpropanoid and cytotoxic norditerpene constituents from Podocarpus nakaii

Syh Yuan Huang
, Long Yun Fan
, Ya Ching Shen
, Chia Ching Liao
, Li Chuan Hsu
, Ya Wen Hsu
, Tian Shan Wu
, Ping Chun Hsiao
, Chien Chang Shen
, Ming Jaw Don
, Yao Haur Kuo

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A new dimeric phenylpropanoid namely podonaka A (1), along with the 13 known compounds including diterpenes (2 and 3), norditerpenes (4 and 5), benzenoids (6-10), steroids (11 and 12), chalcone (13), and megastigmane (14), was isolated from the EtOH extract of Podocarpus nakaii Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR and MS techniques. Biological evaluation showed that norditerpenes, inumakilactone B (4), and podolactone E (5) have potent cytotoxic activities against Daoy, WiDr, KB, and HeLa tumor cell lines. Moreover, low dosage of 5 may induce early apoptosis in KB cells before 12h.

Original language	English
Pages (from-to)	410-416
Number of pages	7
Journal	Journal of Asian Natural Products Research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1080/10286020902877739
Publication status	Published - 2009 May

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1080/10286020902877739

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@article{d4e1290f666e48968a26bd2dca141545,

title = "A new dimeric phenylpropanoid and cytotoxic norditerpene constituents from Podocarpus nakaii",

abstract = "A new dimeric phenylpropanoid namely podonaka A (1), along with the 13 known compounds including diterpenes (2 and 3), norditerpenes (4 and 5), benzenoids (6-10), steroids (11 and 12), chalcone (13), and megastigmane (14), was isolated from the EtOH extract of Podocarpus nakaii Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR and MS techniques. Biological evaluation showed that norditerpenes, inumakilactone B (4), and podolactone E (5) have potent cytotoxic activities against Daoy, WiDr, KB, and HeLa tumor cell lines. Moreover, low dosage of 5 may induce early apoptosis in KB cells before 12h.",

author = "Huang, \{Syh Yuan\} and Fan, \{Long Yun\} and Shen, \{Ya Ching\} and Liao, \{Chia Ching\} and Hsu, \{Li Chuan\} and Hsu, \{Ya Wen\} and Wu, \{Tian Shan\} and Hsiao, \{Ping Chun\} and Shen, \{Chien Chang\} and Don, \{Ming Jaw\} and Kuo, \{Yao Haur\}",

note = "Funding Information: The grants from National Science Council (NSC 93-2320-B-077-007) and National Research Institute of Chinese Medicine, Taiwan (NRICM-96-DHM-02) are gratefully acknowledged. The authors also like to thank NSC Northern MS Instrumental Center in the National Chin-Hua University for the measurement of mass spectra.",

year = "2009",

month = may,

doi = "10.1080/10286020902877739",

language = "English",

volume = "11",

pages = "410--416",

journal = "Journal of Asian Natural Products Research",

issn = "1028-6020",

publisher = "Taylor and Francis Ltd.",

number = "5",

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TY - JOUR

T1 - A new dimeric phenylpropanoid and cytotoxic norditerpene constituents from Podocarpus nakaii

AU - Huang, Syh Yuan

AU - Fan, Long Yun

AU - Shen, Ya Ching

AU - Liao, Chia Ching

AU - Hsu, Li Chuan

AU - Hsu, Ya Wen

AU - Wu, Tian Shan

AU - Hsiao, Ping Chun

AU - Shen, Chien Chang

AU - Don, Ming Jaw

AU - Kuo, Yao Haur

N1 - Funding Information: The grants from National Science Council (NSC 93-2320-B-077-007) and National Research Institute of Chinese Medicine, Taiwan (NRICM-96-DHM-02) are gratefully acknowledged. The authors also like to thank NSC Northern MS Instrumental Center in the National Chin-Hua University for the measurement of mass spectra.

PY - 2009/5

Y1 - 2009/5

N2 - A new dimeric phenylpropanoid namely podonaka A (1), along with the 13 known compounds including diterpenes (2 and 3), norditerpenes (4 and 5), benzenoids (6-10), steroids (11 and 12), chalcone (13), and megastigmane (14), was isolated from the EtOH extract of Podocarpus nakaii Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR and MS techniques. Biological evaluation showed that norditerpenes, inumakilactone B (4), and podolactone E (5) have potent cytotoxic activities against Daoy, WiDr, KB, and HeLa tumor cell lines. Moreover, low dosage of 5 may induce early apoptosis in KB cells before 12h.

AB - A new dimeric phenylpropanoid namely podonaka A (1), along with the 13 known compounds including diterpenes (2 and 3), norditerpenes (4 and 5), benzenoids (6-10), steroids (11 and 12), chalcone (13), and megastigmane (14), was isolated from the EtOH extract of Podocarpus nakaii Hayata. The structure of 1 was elucidated on the basis of spectroscopic analysis including 1D and 2D NMR and MS techniques. Biological evaluation showed that norditerpenes, inumakilactone B (4), and podolactone E (5) have potent cytotoxic activities against Daoy, WiDr, KB, and HeLa tumor cell lines. Moreover, low dosage of 5 may induce early apoptosis in KB cells before 12h.

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UR - https://www.scopus.com/pages/publications/67149136730#tab=citedBy

U2 - 10.1080/10286020902877739

DO - 10.1080/10286020902877739

M3 - Article

C2 - 19504383

AN - SCOPUS:67149136730

SN - 1028-6020

VL - 11

SP - 410

EP - 416

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 5

ER -

A new dimeric phenylpropanoid and cytotoxic norditerpene constituents from Podocarpus nakaii

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