A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam; Shu Duan Jian; Tsong Long Hwang; Po Jen Chen; Hsin Yi Hung; Ping Chung Kuo; Tian Shung Wu

doi:10.1080/14786419.2019.1611809

A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam, Shu Duan Jian, Tsong Long Hwang, Po Jen Chen, Hsin Yi Hung, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

Abstract

A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

Original language	English
Pages (from-to)	17-24
Number of pages	8
Journal	Natural Product Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1080/14786419.2019.1611809
Publication status	Published - 2021

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

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10.1080/14786419.2019.1611809

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title = "A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata",

abstract = "A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.",

author = "Lam, {Sio Hong} and Jian, {Shu Duan} and Hwang, {Tsong Long} and Chen, {Po Jen} and Hung, {Hsin Yi} and Kuo, {Ping Chung} and Wu, {Tian Shung}",

note = "Funding Information: This work was supported by the Ministry of Science and Technology (MOST), Taiwan; the authors are also thankful for partial financial support from Chang Gung Memorial Hospital (CMRPD1B0281?3, CMRPF1D0442?3, CMRPF 1F0011?3, CMRPF1F0061?3 and BMRP450 granted to H.-L.H). Publisher Copyright: {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2021",

doi = "10.1080/14786419.2019.1611809",

language = "English",

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journal = "Natural Product Research",

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AU - Lam, Sio Hong

AU - Jian, Shu Duan

AU - Hwang, Tsong Long

AU - Chen, Po Jen

AU - Hung, Hsin Yi

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

N1 - Funding Information: This work was supported by the Ministry of Science and Technology (MOST), Taiwan; the authors are also thankful for partial financial support from Chang Gung Memorial Hospital (CMRPD1B0281?3, CMRPF1D0442?3, CMRPF 1F0011?3, CMRPF1F0061?3 and BMRP450 granted to H.-L.H). Publisher Copyright: © 2019 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2021

Y1 - 2021

N2 - A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

AB - A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

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A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Abstract

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