A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata

Sio Hong Lam, Shu Duan Jian, Tsong Long Hwang, Po Jen Chen, Hsin Yi Hung, Ping Chung Kuo, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

Abstract

A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalNatural Product Research
Volume35
Issue number1
DOIs
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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