TY - JOUR
T1 - A new urinary antigen test score correlates with severity of pneumococcal pneumonia in children
AU - Shen, Ching Fen
AU - Wang, Shih Min
AU - Liu, Ching Chuan
N1 - Funding Information:
The authors wish to express their appreciation to Dr. Calvin M. Kunin for his critical review of the manuscript. This study was supported by grant from Department of Health, Executive Yuan, Taiwan ( DOH100-TD-B-111-102 ).
PY - 2011/10
Y1 - 2011/10
N2 - Background/Purpose: Streptococcus pneumoniae is the most common bacterial cause of community-acquired pneumonia in children. This study was designed to determine whether a newly designed urinary antigen test score correlated with severity of pneumococcal pneumonia in children. Methods: We recruited 119 children hospitalized with pneumonia diagnosed by positive urinary pneumococcal antigen test at the National Cheng Kung University Hospital from 2002 through 2007. The urinary antigen reactivity score was determined by the rate of the reaction time and intensity of the pneumococcal antigen-antibody band. The children were stratified into three groups according to total score: group I, 8; group II, 5-7; and group III, 2-4. Disease severity was based on clinical presentation and radiological and laboratory findings. Results: Patients in group I had significantly more respiratory distress (p = 0.01), oxygen desaturation (p = 0.04), febrile days (p = 0.03), pulmonary complications (p = 0.01), and bacteremia (p = 0.01), greater requirement for intensive care (p = 0.004), longer hospital stays (p < 0.001), and lower white blood cell counts (p = 0.01) than patients in group II or III. Conclusion: A new urinary pneumococcal antigen test score correlated well with the severity of pneumococcal pneumonia in children. It might provide helpful diagnostic and prognostic information.
AB - Background/Purpose: Streptococcus pneumoniae is the most common bacterial cause of community-acquired pneumonia in children. This study was designed to determine whether a newly designed urinary antigen test score correlated with severity of pneumococcal pneumonia in children. Methods: We recruited 119 children hospitalized with pneumonia diagnosed by positive urinary pneumococcal antigen test at the National Cheng Kung University Hospital from 2002 through 2007. The urinary antigen reactivity score was determined by the rate of the reaction time and intensity of the pneumococcal antigen-antibody band. The children were stratified into three groups according to total score: group I, 8; group II, 5-7; and group III, 2-4. Disease severity was based on clinical presentation and radiological and laboratory findings. Results: Patients in group I had significantly more respiratory distress (p = 0.01), oxygen desaturation (p = 0.04), febrile days (p = 0.03), pulmonary complications (p = 0.01), and bacteremia (p = 0.01), greater requirement for intensive care (p = 0.004), longer hospital stays (p < 0.001), and lower white blood cell counts (p = 0.01) than patients in group II or III. Conclusion: A new urinary pneumococcal antigen test score correlated well with the severity of pneumococcal pneumonia in children. It might provide helpful diagnostic and prognostic information.
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U2 - 10.1016/j.jfma.2011.08.002
DO - 10.1016/j.jfma.2011.08.002
M3 - Article
C2 - 21982464
AN - SCOPUS:80054021458
SN - 0929-6646
VL - 110
SP - 613
EP - 618
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 10
ER -