A novel mesoporous biomaterial for treating dentin hypersensitivity

Y. C. Chiang, H. J. Chen, H. C. Liu, S. H. Kang, B. S. Lee, F. H. Lin, Hong-Ping Lin, C. P. Lin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

An ideal material has yet to be discovered that can completely treat dentin hypersensitivity; however, calcium phosphate precipitation has exhibited potential value for the treatment of dentin hypersensitivity by the occlusion of dentinal tubules. We hypothesized that a novel mesoporous silica biomaterial (nano CaO@mesoporous silica, NCMS) containing nano-sized calcium oxide particles mixed with 30% phosphoric acid can efficiently occlude dentinal tubules and significantly reduce dentin permeability, even with the presence of pulpal pressure. This highly supersaturated Ca 2+ - and HPO 4 2 -ion-containing NCMS paste was brushed onto dentin surfaces, and the ions diffused deeply into the dentinal tubules and formed a CaHPO 4 ·2H 2 O precipitation with a depth of 100 μm. The results of the dentin permeability tests showed that the novel mesoporous material exhibited a significant reduction in dentin permeability (p < 0.05), even under simulated pulpal pressure, as compared with our previously developed material, DP-bioglass, and a commercial desensitizing material, Seal & Protect®.

Original languageEnglish
Pages (from-to)236-240
Number of pages5
JournalJournal of Dental Research
Volume89
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

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Dentin Permeability
Dentin Sensitivity
Biocompatible Materials
Silicon Dioxide
Ions
Pressure
Dentin
Ointments

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Chiang, Y. C., Chen, H. J., Liu, H. C., Kang, S. H., Lee, B. S., Lin, F. H., ... Lin, C. P. (2010). A novel mesoporous biomaterial for treating dentin hypersensitivity. Journal of Dental Research, 89(3), 236-240. https://doi.org/10.1177/0022034509357148
Chiang, Y. C. ; Chen, H. J. ; Liu, H. C. ; Kang, S. H. ; Lee, B. S. ; Lin, F. H. ; Lin, Hong-Ping ; Lin, C. P. / A novel mesoporous biomaterial for treating dentin hypersensitivity. In: Journal of Dental Research. 2010 ; Vol. 89, No. 3. pp. 236-240.
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Chiang, YC, Chen, HJ, Liu, HC, Kang, SH, Lee, BS, Lin, FH, Lin, H-P & Lin, CP 2010, 'A novel mesoporous biomaterial for treating dentin hypersensitivity', Journal of Dental Research, vol. 89, no. 3, pp. 236-240. https://doi.org/10.1177/0022034509357148

A novel mesoporous biomaterial for treating dentin hypersensitivity. / Chiang, Y. C.; Chen, H. J.; Liu, H. C.; Kang, S. H.; Lee, B. S.; Lin, F. H.; Lin, Hong-Ping; Lin, C. P.

In: Journal of Dental Research, Vol. 89, No. 3, 01.03.2010, p. 236-240.

Research output: Contribution to journalArticle

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Chiang YC, Chen HJ, Liu HC, Kang SH, Lee BS, Lin FH et al. A novel mesoporous biomaterial for treating dentin hypersensitivity. Journal of Dental Research. 2010 Mar 1;89(3):236-240. https://doi.org/10.1177/0022034509357148