A novel microtubule inhibitor, MT3-037, causes cancer cell apoptosis by inducing mitotic arrest and interfering with microtubule dynamics

Keyphrases

• Mitotic Arrest 100%
• Microtubule Inhibitor 100%
• Microtubule Dynamics 100%
• Cyclin-dependent Kinase 1 (CDK1) 75%
• Tubulin Polymerization 50%
• Inhibitor of Apoptosis Proteins 25%
• Pro-apoptotic Factors 25%
• Molecular Docking Studies 25%
• Synthetic Compounds 25%
• 3-fluorophenyl 25%
• Cancer Cell Viability 25%
• MDA-MB-468 25%
• Polo-like Kinase 1 (PLK1) 25%
• Survivin 25%
• Mitotic Spindle 25%
• Cleavage Activation 25%
• Bcl-xL 25%
• Spindle Dynamics 25%
• Immunofluorescence Staining 25%
• Anticancer Potential 25%
• Polymerization Assays 25%
• Xenograft Mouse Model 25%

Biochemistry, Genetics and Molecular Biology

• Mitosis Inhibition 100%
• Cyclin-Dependent Kinase 1 75%
• MDA-MB-468 25%
• Inhibitor of Apoptosis 25%
• Polo-Like Kinase 1 25%
• Docking (Molecular) 25%
• Bcl-xL 25%
• Cyclin B1 25%
• Mitosis Spindle 25%
• FADD 25%
• Survivin 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Microtubule Inhibitors 100%
• Cyclin Dependent Kinase 1 50%
• Polo Like Kinase 1 16%
• Survivin 16%
• Apoptosis Inhibitor 16%