A novel one-pot synthesis of 2-arylpyrazoloquinolinone derivatives

En Chiuan Chang, Ya Lan Wen, Chun Hsi Chang, Yun Hwei Shen, Shaw Bing Wen, Mou Yung Yeh, Fung Fuh Wong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Two regioisomers of 2-arylpyrazolo[3,4-c]quinolin-4(5H)-ones and 2-arylpyrazolo[4,3-c]quinolin-4(5H)-ones were synthesized by utilizing 3-arylsydnones, ethyl 3-bromopropynoate, and 2-aminophenylboronic acid pinacol ester in presence of catalytic agent Pd(PPh 3) 4. This efficient one-pot synthesis methodology involved 1,3-dipolar cycloaddition, Suzuki coupling reaction, and intramolecular cyclization three sequence steps.

Original languageEnglish
Pages (from-to)5920-5924
Number of pages5
JournalTetrahedron
Volume68
Issue number29
DOIs
Publication statusPublished - 2012 Jul 22

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Chang, E. C., Wen, Y. L., Chang, C. H., Shen, Y. H., Wen, S. B., Yeh, M. Y., & Wong, F. F. (2012). A novel one-pot synthesis of 2-arylpyrazoloquinolinone derivatives. Tetrahedron, 68(29), 5920-5924. https://doi.org/10.1016/j.tet.2012.04.093