A novel oxidative free radical reaction between 2-hydroxy-1,4-naphthoquinone and β-enamino carbonyl compounds

Che Ping Chuang, Yi Lung Wu

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The manganese(III) initiated oxidative free radical reaction between 2-hydroxy-1,4-naphthoquinone and β-enamino carbonyl compound 2 is described. Enamine radical 5 can be generated effectively from the oxidation of enamine 2 by manganese(III) acetate. Spirolactam 3 was prepared effectively from readily available 2-hydroxy-1,4-naphthoquinone and enamine 2.

Original languageEnglish
Pages (from-to)1717-1719
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number9
DOIs
Publication statusPublished - 2001 Feb 26

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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