A novel zwitterionic polymer for surface modification of polypropylene

Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility

Chia Sheng Hung, Chi Hui Cheng, Jui-Che Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Antifouling is one of the most important characteristics required for materials intended for biomedical applications. In can lead to the reducing protein adsorption and subsequent bacterial adhesion or platelet adhesion. It is hypothesized that the nonfouling ability is tightly correlated with a hydration layer near the surface which forms a physical and energetic barrier to prevent protein adsorption on the surface. So far, there are three hydrophilic materials, 2-hydroxyethyl methacrylate (HEMA), oligo (ethylene glycol) (OEG) or poly (ethylene glycol) (PEG) and zwitterionic polymers have been suggested to be resistant to protein adsorption in different testing settings. But the failure in protein adsorption testing in physiological relevant conditions (e.g. undiluted human blood serum or plasma) for the polyHEMA and likely decomposition of PEG and OEG groups by the oxygen and transition metal ions found in most biochemically relevant solutions have rendered the zwitterionic materials to be the choice for preparing the nonfouling surface layer.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019 Jan 1
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19-04-0319-04-06

Fingerprint

Ethylene Glycol
Polypropylenes
Adsorption
Surface treatment
Polymers
Adhesion
Proteins
Ethylene glycol
Polyethylene glycols
Bacterial Adhesion
Architectural Accessibility
Testing
Platelets
Hydration
Transition metals
Metal ions
Blood
Blood Platelets
Metals
Ions

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Hung, C. S., Cheng, C. H., & Lin, J-C. (2019). A novel zwitterionic polymer for surface modification of polypropylene: Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Hung, Chia Sheng ; Cheng, Chi Hui ; Lin, Jui-Che. / A novel zwitterionic polymer for surface modification of polypropylene : Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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Hung, CS, Cheng, CH & Lin, J-C 2019, A novel zwitterionic polymer for surface modification of polypropylene: Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 19-04-03.

A novel zwitterionic polymer for surface modification of polypropylene : Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility. / Hung, Chia Sheng; Cheng, Chi Hui; Lin, Jui-Che.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Hung CS, Cheng CH, Lin J-C. A novel zwitterionic polymer for surface modification of polypropylene: Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).