A novel zwitterionic polymer for surface modification of polypropylene: Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility

Chia Sheng Hung, Chi Hui Cheng, Jui-Che Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Antifouling is one of the most important characteristics required for materials intended for biomedical applications. In can lead to the reducing protein adsorption and subsequent bacterial adhesion or platelet adhesion. It is hypothesized that the nonfouling ability is tightly correlated with a hydration layer near the surface which forms a physical and energetic barrier to prevent protein adsorption on the surface. So far, there are three hydrophilic materials, 2-hydroxyethyl methacrylate (HEMA), oligo (ethylene glycol) (OEG) or poly (ethylene glycol) (PEG) and zwitterionic polymers have been suggested to be resistant to protein adsorption in different testing settings. But the failure in protein adsorption testing in physiological relevant conditions (e.g. undiluted human blood serum or plasma) for the polyHEMA and likely decomposition of PEG and OEG groups by the oxygen and transition metal ions found in most biochemically relevant solutions have rendered the zwitterionic materials to be the choice for preparing the nonfouling surface layer.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - 2019 Jan 1
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 2019 Apr 32019 Apr 6

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period19-04-0319-04-06

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Fingerprint Dive into the research topics of 'A novel zwitterionic polymer for surface modification of polypropylene: Synthesis, surface characterization, antimicrobial adhesion and hemocompatibility'. Together they form a unique fingerprint.

Cite this