A numerical simulation of intimal thickening under shear in arteries

Denz Lee, J. J. Chiu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A model of intima thickening proposed by Friedman and his coworkers is incorporated in our computer code to simulate the growth of intima under shear. The computer code is based on a finite volume method in a boundary-fitted coordinate system. It is found that the model yields an evenly-distributed thickening over a straight, smooth vessel wall. However, in a stenosed or a curved artery, thicker intima can be formed in preferential regions due to unevenly-distributed wall shear stresses. The results clearly demonstrate the correlations among the geometry, wall shear rate and the plaque localization in arteries. The model is applied to a straight artery with a stenosis of sinus, a smooth curved artery and a stenosed curved artery. The effects of stenosis/sinus and lumen curvature on the flows and the intimal thickening are studied. The simulation provides a numerical visualization of the intimal thickening in a dynamic way.

Original languageEnglish
Pages (from-to)337-351
Number of pages15
JournalBiorheology
Volume29
Issue number2-3
DOIs
Publication statusPublished - 1992 Jan 1

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Tunica Intima
Arteries
Pathologic Constriction
Growth

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Lee, Denz ; Chiu, J. J. / A numerical simulation of intimal thickening under shear in arteries. In: Biorheology. 1992 ; Vol. 29, No. 2-3. pp. 337-351.
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A numerical simulation of intimal thickening under shear in arteries. / Lee, Denz; Chiu, J. J.

In: Biorheology, Vol. 29, No. 2-3, 01.01.1992, p. 337-351.

Research output: Contribution to journalArticle

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