TY - JOUR
T1 - A Pan-Cancer Immunogenomic Atlas for Immune Checkpoint Blockade Immunotherapy
AU - Yang, Jing
AU - Zhao, Shilin
AU - Wang, Jing
AU - Sheng, Quanhu
AU - Liu, Qi
AU - Shyr, Yu
N1 - Publisher Copyright:
© 2022 American Association for Cancer Research Inc.. All rights reserved.
PY - 2022/2/15
Y1 - 2022/2/15
N2 - The ability to identify robust genomic signatures that predict response to immune checkpoint blockade is restricted by limited sample sizes and ungeneralizable performance across cohorts. To address these challenges, we established CancerImmu (http://bioinfo.vanderbilt.edu/database/Cancer-Immu/), a comprehensive platform that integrates large-scale multidimensional omics data, including genetic, bulk, and singlecell transcriptomic, proteomic, and dynamic genomic profiles, with clinical phenotypes to explore consistent and rare immunogenomic connections. Currently Cancer-Immu has incorporated data for 3,652 samples for 16 cancer types. It provides easy access to immunogenomic data and empowers researchers to translate omics datasets into biological insights and clinical applications. Significance:Cancer-Immu is a comprehensive functional portal for unraveling immune-genomic connections to improve immune checkpoint blockade-based cancer immunotherapy.
AB - The ability to identify robust genomic signatures that predict response to immune checkpoint blockade is restricted by limited sample sizes and ungeneralizable performance across cohorts. To address these challenges, we established CancerImmu (http://bioinfo.vanderbilt.edu/database/Cancer-Immu/), a comprehensive platform that integrates large-scale multidimensional omics data, including genetic, bulk, and singlecell transcriptomic, proteomic, and dynamic genomic profiles, with clinical phenotypes to explore consistent and rare immunogenomic connections. Currently Cancer-Immu has incorporated data for 3,652 samples for 16 cancer types. It provides easy access to immunogenomic data and empowers researchers to translate omics datasets into biological insights and clinical applications. Significance:Cancer-Immu is a comprehensive functional portal for unraveling immune-genomic connections to improve immune checkpoint blockade-based cancer immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85124880395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85124880395&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-21-2335
DO - 10.1158/0008-5472.CAN-21-2335
M3 - Article
C2 - 34903605
AN - SCOPUS:85124880395
SN - 0008-5472
VL - 82
SP - 539
EP - 542
JO - Cancer Research
JF - Cancer Research
IS - 4
ER -