A pharmacokinetic study of nimesulide in healthy volunteers: Correlation between in vitro dissolution and in vivo absorption

Sheng Fang Su, Jin Ding Huang, Chen Hsi Chou, Chia Wei Chu, Chia Ling Hsiao, Chao Feng Kung, Hwei Ling Lee, Chyun Yu Yang

Research output: Contribution to journalArticlepeer-review

Abstract

Nimesulide is a non-steroid anti-inflammatory drug (NSAID) used for the treatment of inflammation and pain. Twelve healthy volunteers were recruited for this study to evaluate the bioequivalence of two nimesulide formulations and to further understand the effects of in vitro dissolution on in vivo absorption. After oral administration of 100 mg of nimesulide, maximal concentrations of 4-6 μg/mL were reached after 2-3 hours. A smaller Cmax and longer Tmax was observed in formulation N, but no difference in t1/2 was found between the two formulations. In addition, a 17 % reduction in AUC was observed for formulation N, indicating that the extent and rate of absorption of nimesulide were not equivalent between two formulations. The results from in vitro dissolution tests showed that 80 % of nimesulide was released in 20 minutes from formulation A, while only 60 % was released in 3 hours from formulation N. This study suggests that the differences in dissolution can account for differences in absorption of nimesulide in vivo.

Original languageEnglish
Pages (from-to)281-290
Number of pages10
JournalChinese Pharmaceutical Journal
Volume53
Issue number6
Publication statusPublished - 2001 Dec 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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