TY - JOUR
T1 - A population-based study of epilepsy incidence in association with type 2 diabetes and severe hypoglycaemia
AU - Lu, Chin Li
AU - Chang, Ya Hui
AU - Sun, Yu
AU - Li, Chung Yi
N1 - Funding Information:
This study was supported by a grant from the Ministry of Science and Technology ( MOST 104-2314-B-006-020-MY2 ). The funder had no role in conducting and submitting this work. All authors declare that there is no conflict of interest associated with this manuscript. Appendix A
Funding Information:
This study is based in part on data from the NHIRD provided by the National Health Insurance Administration, Ministry of Health and Welfare of Taiwan, and managed by the National Health Research Institutes. The interpretation and conclusions contained herein do not represent the views of the National Health Insurance Administration, Ministry of Health and Welfare of Taiwan or National Health Research Institutes.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/6
Y1 - 2018/6
N2 - Aims: This study was conducted to investigate potential link between type 2 diabetes mellitus (T2DM) and epilepsy, and the role of severe hypoglycaemia (SH) might play in the relationship. Methods: This was a cohort study based on Taiwan's National Health insurance claims. Totally 751,792 people with T2DM and 824,253 matched controls were identified in 2002–2003 and followed to incidence of epilepsy or end of 2011. We used Cox proportional hazard model to relate epilepsy incidence to separate and joint effects of T2DM and SH. A possible mediation effect of SH on the association between T2DM and epilepsy was analyzed. Results: Over a 10-year follow-up, patients with T2DM had a higher incidence rate of epilepsy than controls (35.0 vs 21.9 per 10,000 person-years). After controlling for potential confounders including SH, T2DM increased the hazard of epilepsy by some 50%. The stratified analysis further indicated that T2DM (hazard ratio (HR)=1.44, 95% confidence interval (CI) = 1.40–1.47), and SH (HR = 2.22, 95% CI = 1.76–2.81) were both independent risk factors for epilepsy. SH did not modify but mediated 12% of the association between T2DM and epilepsy. Conclusion: Our findings supported that SH may increase the risk of epilepsy, and that T2DM may increase risk of epilepsy independent of SH.
AB - Aims: This study was conducted to investigate potential link between type 2 diabetes mellitus (T2DM) and epilepsy, and the role of severe hypoglycaemia (SH) might play in the relationship. Methods: This was a cohort study based on Taiwan's National Health insurance claims. Totally 751,792 people with T2DM and 824,253 matched controls were identified in 2002–2003 and followed to incidence of epilepsy or end of 2011. We used Cox proportional hazard model to relate epilepsy incidence to separate and joint effects of T2DM and SH. A possible mediation effect of SH on the association between T2DM and epilepsy was analyzed. Results: Over a 10-year follow-up, patients with T2DM had a higher incidence rate of epilepsy than controls (35.0 vs 21.9 per 10,000 person-years). After controlling for potential confounders including SH, T2DM increased the hazard of epilepsy by some 50%. The stratified analysis further indicated that T2DM (hazard ratio (HR)=1.44, 95% confidence interval (CI) = 1.40–1.47), and SH (HR = 2.22, 95% CI = 1.76–2.81) were both independent risk factors for epilepsy. SH did not modify but mediated 12% of the association between T2DM and epilepsy. Conclusion: Our findings supported that SH may increase the risk of epilepsy, and that T2DM may increase risk of epilepsy independent of SH.
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U2 - 10.1016/j.diabres.2018.03.020
DO - 10.1016/j.diabres.2018.03.020
M3 - Article
C2 - 29608979
AN - SCOPUS:85045111214
SN - 0168-8227
VL - 140
SP - 97
EP - 106
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
ER -