A portable electrochemical sensor for caffeine and (-)epigallocatechin gallate based on molecularly imprinted poly(ethylene-co-vinyl alcohol) recognition element

I. Chegn Chung, Chih Chun Chang, Han Sheng Chiu, Shih Fan Jiang, Mei Hwa Lee, Cho Liang Chung, Bin Da Liu, Chun Yueh Huang, Hung Yin Lin

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The U.S. Food and Drug Administration allows a maximum of 72 mg of caffeine per 12 oz. serving (6 mg/oz). Consuming 400 mg of caffeine 3 times daily for 7 days may develop sleep disruption effects. However, it is still very hard for people to estimate how much caffeine is intake daily. Moreover, (-)epigallocatechin gallate (EGCG) is studied a potent antioxidant that may have therapeutic properties for anti-aging and cancer. Conventionally, both caffeine and EGCG could be measured by the protocols of high performance liquid chromatography; however, high precision instruments are required. In this work, the caffeine and EGCG are used as the template molecules and imprinted into poly(ethylene-co-vinyl alcohol), EVAL, via solvent evaporation. The EVAL membrane is then used as the sensing element for electrochemical analysis after templates removal. From the cyclic voltammetry measurement of the caffeine, the peak oxidation potential is shifted from 0.36 to 0.46 V when the final concentration of caffeine is from 0.01 to 1 mg/mL, and the highest current density is about 0.18 μA/cm2. The caffeine and EGCG concentrations measured in three real samples are about 0.10-0.13 mg/mL and 0.49-1.74 mg/mL, respectively. This molecularly imprinted polymeric coated electrode is potential employed as a home-care system.

Original languageEnglish
Pages (from-to)10633-10638
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume11
Issue number12
DOIs
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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