A portable low-power acquisition system with a urease bioelectrochemical sensor for potentiometric detection of urea concentrations

Wei Jhe Ma, Ching Hsing Luo, Jiun Ling Lin, Sin Houng Chou, Ping Hung Chen, Mei Jywan Syu, Shin Hung Kuo, Shin Chi Lai

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

This paper presents a portable low-power battery-driven bioelectrochemical signal acquisition system for urea detection. The proposed design has several advantages, including high performance, low cost, low-power consumption, and high portability. A LT1789-1 low-supply-voltage instrumentation amplifier (IA) was used to measure and amplify the open-circuit potential (OCP) between the working and reference electrodes. An MSP430 micro-controller was programmed to process and transduce the signals to the custom-developed software by ZigBee RF module in wireless mode and UART in able mode. The immobilized urease sensor was prepared by embedding urease into the polymer (aniline-co-o-phenylenediamine) polymeric matrix and then coating/depositing it onto a MEMS-fabricated Au working electrode. The linear correlation established between the urea concentration and the potentiometric change is in the urea concentrations range of 3.16 × 10-4 to 3.16 × 10-2 M with a sensitivity of 31.12 mV/log [M] and a precision of 0.995 (R2 = 0.995). This portable device not only detects urea concentrations, but can also operate continuously with a 3.7 V rechargeable lithium-ion battery (500 mA·h) for at least four days. Accordingly, its use is feasible and even promising for home-care applications.

Original languageEnglish
Article number474
JournalSensors (Switzerland)
Volume16
Issue number4
DOIs
Publication statusPublished - 2016 Apr 2

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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