A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic

Chen Hsun Weng, Hsin Yi Chou, Ming Huang Chen, Yu Sheng Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Vitamin D deficiency has been linked to several diseases and adverse outcomes including: diabetes, cardiovascular diseases, and even cancer. At present the clear majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a paper-based microfluidic system for rapid quantification of vitamin D levels on a portable platform. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 25 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results.

Original languageEnglish
Title of host publicationBMEiCON 2018 - 11th Biomedical Engineering International Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538657249
DOIs
Publication statusPublished - 2019 Jan 10
Event11th Biomedical Engineering International Conference, BMEiCON 2018 - Chaing Mai, Thailand
Duration: 2018 Nov 212018 Nov 24

Publication series

NameBMEiCON 2018 - 11th Biomedical Engineering International Conference

Conference

Conference11th Biomedical Engineering International Conference, BMEiCON 2018
CountryThailand
CityChaing Mai
Period18-11-2118-11-24

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All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Biomedical Engineering
  • Instrumentation

Cite this

Weng, C. H., Chou, H. Y., Chen, M. H., & Lin, Y. S. (2019). A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic. In BMEiCON 2018 - 11th Biomedical Engineering International Conference [8609988] (BMEiCON 2018 - 11th Biomedical Engineering International Conference). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BMEiCON.2018.8609988