TY - GEN
T1 - A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic
AU - Weng, Chen Hsun
AU - Chou, Hsin Yi
AU - Chen, Ming Huang
AU - Lin, Yu-Sheng
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2019/1/10
Y1 - 2019/1/10
N2 - Vitamin D deficiency has been linked to several diseases and adverse outcomes including: diabetes, cardiovascular diseases, and even cancer. At present the clear majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a paper-based microfluidic system for rapid quantification of vitamin D levels on a portable platform. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 25 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results.
AB - Vitamin D deficiency has been linked to several diseases and adverse outcomes including: diabetes, cardiovascular diseases, and even cancer. At present the clear majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a paper-based microfluidic system for rapid quantification of vitamin D levels on a portable platform. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 25 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results.
UR - http://www.scopus.com/inward/record.url?scp=85062055809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062055809&partnerID=8YFLogxK
U2 - 10.1109/BMEiCON.2018.8609988
DO - 10.1109/BMEiCON.2018.8609988
M3 - Conference contribution
AN - SCOPUS:85062055809
T3 - BMEiCON 2018 - 11th Biomedical Engineering International Conference
BT - BMEiCON 2018 - 11th Biomedical Engineering International Conference
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 11th Biomedical Engineering International Conference, BMEiCON 2018
Y2 - 21 November 2018 through 24 November 2018
ER -
