A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic

Chen Hsun Weng; Hsin Yi Chou; Ming Huang Chen; Yu-Sheng Lin

doi:10.1109/BMEiCON.2018.8609988

A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic

Chen Hsun Weng
, Hsin Yi Chou
, Ming Huang Chen
, Yu-Sheng Lin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Citations (Scopus)

Abstract

Vitamin D deficiency has been linked to several diseases and adverse outcomes including: diabetes, cardiovascular diseases, and even cancer. At present the clear majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a paper-based microfluidic system for rapid quantification of vitamin D levels on a portable platform. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 25 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results.

Original language	English
Title of host publication	BMEiCON 2018 - 11th Biomedical Engineering International Conference
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781538657249
DOIs	https://doi.org/10.1109/BMEiCON.2018.8609988
Publication status	Published - 2019 Jan 10
Event	11th Biomedical Engineering International Conference, BMEiCON 2018 - Chaing Mai, Thailand Duration: 2018 Nov 21 → 2018 Nov 24

Publication series

Name	BMEiCON 2018 - 11th Biomedical Engineering International Conference

Conference

Conference	11th Biomedical Engineering International Conference, BMEiCON 2018
Country/Territory	Thailand
City	Chaing Mai
Period	18-11-21 → 18-11-24

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Artificial Intelligence
Biomedical Engineering
Instrumentation

Access to Document

10.1109/BMEiCON.2018.8609988

Cite this

Weng, C. H., Chou, H. Y., Chen, M. H., & Lin, Y.-S. (2019). A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic. In BMEiCON 2018 - 11th Biomedical Engineering International Conference Article 8609988 (BMEiCON 2018 - 11th Biomedical Engineering International Conference). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BMEiCON.2018.8609988

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title = "A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic",

abstract = "Vitamin D deficiency has been linked to several diseases and adverse outcomes including: diabetes, cardiovascular diseases, and even cancer. At present the clear majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a paper-based microfluidic system for rapid quantification of vitamin D levels on a portable platform. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 25 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results.",

author = "Weng, \{Chen Hsun\} and Chou, \{Hsin Yi\} and Chen, \{Ming Huang\} and Yu-Sheng Lin",

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doi = "10.1109/BMEiCON.2018.8609988",

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Weng, CH, Chou, HY, Chen, MH & Lin, Y-S 2019, A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic. in BMEiCON 2018 - 11th Biomedical Engineering International Conference., 8609988, BMEiCON 2018 - 11th Biomedical Engineering International Conference, Institute of Electrical and Electronics Engineers Inc., 11th Biomedical Engineering International Conference, BMEiCON 2018, Chaing Mai, Thailand, 18-11-21. https://doi.org/10.1109/BMEiCON.2018.8609988

A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic. / Weng, Chen Hsun; Chou, Hsin Yi; Chen, Ming Huang et al.
BMEiCON 2018 - 11th Biomedical Engineering International Conference. Institute of Electrical and Electronics Engineers Inc., 2019. 8609988 (BMEiCON 2018 - 11th Biomedical Engineering International Conference).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Weng, Chen Hsun

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AU - Chen, Ming Huang

AU - Lin, Yu-Sheng

PY - 2019/1/10

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N2 - Vitamin D deficiency has been linked to several diseases and adverse outcomes including: diabetes, cardiovascular diseases, and even cancer. At present the clear majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a paper-based microfluidic system for rapid quantification of vitamin D levels on a portable platform. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 25 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results.

AB - Vitamin D deficiency has been linked to several diseases and adverse outcomes including: diabetes, cardiovascular diseases, and even cancer. At present the clear majority of vitamin D testing is performed in large-scale laboratories at the request of a physician as part of an annual panel of blood tests. Here we present a paper-based microfluidic system for rapid quantification of vitamin D levels on a portable platform. The system consists of a smartphone accessory, an app, and a test strip that allows the colorimetric detection of 25-hydroxyvitamin D using a novel gold nanoparticle-based immunoassay. We show that the system can be used to accurately measure physiological levels of 25-hydroxyvitamin D with accuracy better than 25 nM and a precision of 10 nM. We compare our system with well-established ELISA test kits for serum samples of unknown concentration and demonstrate equivalency of the results.

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M3 - Conference contribution

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Weng CH, Chou HY, Chen MH, Lin YS. A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic. In BMEiCON 2018 - 11th Biomedical Engineering International Conference. Institute of Electrical and Electronics Engineers Inc. 2019. 8609988. (BMEiCON 2018 - 11th Biomedical Engineering International Conference). doi: 10.1109/BMEiCON.2018.8609988

A portable platform for the quantification of Vitamin D levels by using paper-based microfluidic

Abstract

Publication series

Conference

UN SDGs

All Science Journal Classification (ASJC) codes

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