A portable wireless online closed-loop seizure controller in freely moving rats

Chung Ping Young, Sheng Fu Liang, Da Wei Chang, Yi Cheng Liao, Fu Zen Shaw, Chao Hsien Hsieh

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

A considerable portion of epilepsy cannot be well treated by available therapies nowadays. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. A portable wireless online closed-loop seizure controller in freely moving rats was developed and shown with several aspects of advantages, including the following: 1) high accuracy of real-time seizure detection (9299% during wakesleep states); 2) low cost; and 3) low power consumption. The seizure detection latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. The observation showed that the stimulation elicited no abnormal behavior and had no sleep interruption to the subjects. The experiment data supported the functional possibility of a real-time closed-loop seizure controller.

Original languageEnglish
Article number5499016
Pages (from-to)513-521
Number of pages9
JournalIEEE Transactions on Instrumentation and Measurement
Volume60
Issue number2
DOIs
Publication statusPublished - 2011 Feb

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Electrical and Electronic Engineering

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