A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder

Liang Jen Wang, Sheng Yu Lee, Shiou Lan Chen, Yun Hsuan Chang, Po See Chen, San Yuan Huang, Nian Sheng Tzeng, Kao Chin Chen, I. Hui Lee, Tzu Yun Wang, Yen Kuang Yang, Ru-Band Lu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in psychiatric settings. Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function. The current study examined the association and interaction of the COMT Val158Met and MTHFR C677T variants with BP-II. Nine hundred seventy-eight participants were recruited: 531 with BP-II and 447 healthy controls. The genotypes of the COMT and MTHFR polymorphisms were determined using a polymerase chain reaction-restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II.

Original languageEnglish
Article number8813
JournalScientific reports
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • General


Dive into the research topics of 'A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder'. Together they form a unique fingerprint.

Cite this