A potential role of p53 and WOX1 in mitochondrial apoptosis (review).

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

A large number of p53-transcribed proteins have been shown to mediate growth arrest and/or apoptosis in vitro, whereas their in vivo roles remain largely unclear. p53 is capable of initiating apoptosis without transcription of apoptosis inducer genes, although the underlying mechanism is unknown. p53 is present in the mitochondria and appears to contribute to the biogenesis, function and apoptosis of this organelle. We have recently cloned a p53-binding mitochondrial WW domain-containing oxidoreductase (WOX1). Suppression of WOX1 expression abolishes p53 apoptotic function, indicating that WOX1 is a likely partner of p53 in cell death. In this review article, the potential role of WOX1/p53 as a signaling complex in the mitochondrial apoptosis is discussed.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalInternational journal of molecular medicine
Volume9
Issue number1
Publication statusPublished - 2002 Jan 1

Fingerprint

Apoptosis
Organelles
Mitochondria
Oxidoreductases
Cell Death
Growth
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

@article{2469f8cfb07f4cef8e6f6a13130a438b,
title = "A potential role of p53 and WOX1 in mitochondrial apoptosis (review).",
abstract = "A large number of p53-transcribed proteins have been shown to mediate growth arrest and/or apoptosis in vitro, whereas their in vivo roles remain largely unclear. p53 is capable of initiating apoptosis without transcription of apoptosis inducer genes, although the underlying mechanism is unknown. p53 is present in the mitochondria and appears to contribute to the biogenesis, function and apoptosis of this organelle. We have recently cloned a p53-binding mitochondrial WW domain-containing oxidoreductase (WOX1). Suppression of WOX1 expression abolishes p53 apoptotic function, indicating that WOX1 is a likely partner of p53 in cell death. In this review article, the potential role of WOX1/p53 as a signaling complex in the mitochondrial apoptosis is discussed.",
author = "Nan-Shan Chang",
year = "2002",
month = "1",
day = "1",
language = "English",
volume = "9",
pages = "19--24",
journal = "International Journal of Molecular Medicine",
issn = "1107-3756",
publisher = "Spandidos Publications",
number = "1",

}

A potential role of p53 and WOX1 in mitochondrial apoptosis (review). / Chang, Nan-Shan.

In: International journal of molecular medicine, Vol. 9, No. 1, 01.01.2002, p. 19-24.

Research output: Contribution to journalReview article

TY - JOUR

T1 - A potential role of p53 and WOX1 in mitochondrial apoptosis (review).

AU - Chang, Nan-Shan

PY - 2002/1/1

Y1 - 2002/1/1

N2 - A large number of p53-transcribed proteins have been shown to mediate growth arrest and/or apoptosis in vitro, whereas their in vivo roles remain largely unclear. p53 is capable of initiating apoptosis without transcription of apoptosis inducer genes, although the underlying mechanism is unknown. p53 is present in the mitochondria and appears to contribute to the biogenesis, function and apoptosis of this organelle. We have recently cloned a p53-binding mitochondrial WW domain-containing oxidoreductase (WOX1). Suppression of WOX1 expression abolishes p53 apoptotic function, indicating that WOX1 is a likely partner of p53 in cell death. In this review article, the potential role of WOX1/p53 as a signaling complex in the mitochondrial apoptosis is discussed.

AB - A large number of p53-transcribed proteins have been shown to mediate growth arrest and/or apoptosis in vitro, whereas their in vivo roles remain largely unclear. p53 is capable of initiating apoptosis without transcription of apoptosis inducer genes, although the underlying mechanism is unknown. p53 is present in the mitochondria and appears to contribute to the biogenesis, function and apoptosis of this organelle. We have recently cloned a p53-binding mitochondrial WW domain-containing oxidoreductase (WOX1). Suppression of WOX1 expression abolishes p53 apoptotic function, indicating that WOX1 is a likely partner of p53 in cell death. In this review article, the potential role of WOX1/p53 as a signaling complex in the mitochondrial apoptosis is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0036134649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036134649&partnerID=8YFLogxK

M3 - Review article

C2 - 11744990

AN - SCOPUS:0036134649

VL - 9

SP - 19

EP - 24

JO - International Journal of Molecular Medicine

JF - International Journal of Molecular Medicine

SN - 1107-3756

IS - 1

ER -