This paper presents an application specific integrated circuit (ASIC) for electrochemistry acquisition with a high power-efficient current readout circuit. The proposed ASIC includes a current-sensing voltage-controlled oscillator (VCO)-based continuous-time delta-sigma modulator (CTDSM), a decimation filter, an UART package generator and low-dropout regulators. The proposed VCO-based CTDSM features direct connection to the electrochemical sensor without pre-amplifier, which can directly quantize the reaction current signal to achieve a better power efficiency. Second order noise shaping is achieved by using an additional capacitor as a passive integrator and a dual-VCO structure as an integrator in phase domain. The digital circuitry mainly functions as a decimation filter and an UART package generator. The proposed ASIC implemented in TSMC 0.18μm CMOS process can achieve 73 dB dynamic range (DR) and power efficiency of 0.73 while consuming only 73.9 μW. The total chip area is 2.25 mm2.