Pulse wave velocity (PWV) is the most popular index to assess the arterial stiffness. Recently, several non-invasive examination methods with single channel for PWV are announced. This paper proposes a non-invasive digital volume pulse (DVP) measuring system using a dual channel simultaneous measurement method and tries to meet the demands for home healthcare equipment which is easy to operate. Through synchronal technical in measuring DVP signals from finger and toe can achieve more precise time and substantially reduces the time spend in measurement procedures. On the other hand, the proposed system developed an algorithm to locate the "Foot of the wave" without facilitating of electrocardiogram (ECG). In terms of device and computer data transmission, this paper adopts communication interface Universal Serial Bus(USB), In spite of the advantage of USB interface, RS-232 is gradually out of use and USB can only be found to be used in the notebooks. Such fact causes doctors' inconvenience to carry notebooks and PWV around to measure artery sclerosis. The paper, hence, combines USB communication interface and PWV device, in hopes of maximizing the user-friendly function of such device.