A rapid paper-based detection system for determination of human serum albumin concentration

Ruey Jen Yang, Chin Chung Tseng, Wei Jhong Ju, Hsiang Li Wang, Lung Ming Fu

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


A rapid analytical platform composed of a paper-based chip (µPB-Chip) and a small analytic box is developed to determine the concentration of human serum albumin (HSA). In this study, a Bromocresol Green (BCG) reagent is dropped into the reaction area of the µPB-Chip, and the HSA concentration was derived from the R (red) value intensity of the albumin-BCG complex formed after a reaction process at 37 °C for 12 min. The effectiveness of the developed method is displayed using albumin concentrations ranging from 0 to 5 g/dL in HSA control samples. The measurement results acquired from 36 volunteer patient's HSA samples are presented to be in good consistency with those obtained utilizing a conventional assay technique (R2 = 0.9912). Ultimately, the results show that the developed platform provides a convenient, economical and dependable method for HSA concentration detection.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalChemical Engineering Journal
Publication statusPublished - 2018 Nov 15

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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