A re-evaluation of the mechanisms leading to dengue hemorrhagic fever

Sansanee Noisakran, Kulkanya Chokephaibulkit, Pucharee Songprakhon, Nattawat Onlamoon, Hui Mien Hsiao, Francois Villinger, Aftab Ansari, Guey-Chuen Perng

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHFDSS. Lack of a suitable animal model for DHFDSS has hindered progress in defining the etiology of DHFDSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients.

Original languageEnglish
JournalAnnals of the New York Academy of Sciences
Volume1171
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2009 Jan 1

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Severe Dengue
Dengue Virus
Viruses
Dengue
Viremia
Virus Diseases
Platelets
Blood Platelets
Flavivirus
Cell Lineage
Animals
Animal Models
Observation
Technology
Virus
Fever
Evaluation
Infection
Illness

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Noisakran, S., Chokephaibulkit, K., Songprakhon, P., Onlamoon, N., Hsiao, H. M., Villinger, F., ... Perng, G-C. (2009). A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Annals of the New York Academy of Sciences, 1171(SUPPL. 1). https://doi.org/10.1111/j.1749-6632.2009.05050.x
Noisakran, Sansanee ; Chokephaibulkit, Kulkanya ; Songprakhon, Pucharee ; Onlamoon, Nattawat ; Hsiao, Hui Mien ; Villinger, Francois ; Ansari, Aftab ; Perng, Guey-Chuen. / A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. In: Annals of the New York Academy of Sciences. 2009 ; Vol. 1171, No. SUPPL. 1.
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Noisakran, S, Chokephaibulkit, K, Songprakhon, P, Onlamoon, N, Hsiao, HM, Villinger, F, Ansari, A & Perng, G-C 2009, 'A re-evaluation of the mechanisms leading to dengue hemorrhagic fever', Annals of the New York Academy of Sciences, vol. 1171, no. SUPPL. 1. https://doi.org/10.1111/j.1749-6632.2009.05050.x

A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. / Noisakran, Sansanee; Chokephaibulkit, Kulkanya; Songprakhon, Pucharee; Onlamoon, Nattawat; Hsiao, Hui Mien; Villinger, Francois; Ansari, Aftab; Perng, Guey-Chuen.

In: Annals of the New York Academy of Sciences, Vol. 1171, No. SUPPL. 1, 01.01.2009.

Research output: Contribution to journalReview article

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Noisakran S, Chokephaibulkit K, Songprakhon P, Onlamoon N, Hsiao HM, Villinger F et al. A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Annals of the New York Academy of Sciences. 2009 Jan 1;1171(SUPPL. 1). https://doi.org/10.1111/j.1749-6632.2009.05050.x