A re-evaluation of the mechanisms leading to dengue hemorrhagic fever

Sansanee Noisakran, Kulkanya Chokephaibulkit, Pucharee Songprakhon, Nattawat Onlamoon, Hui Mien Hsiao, Francois Villinger, Aftab Ansari, Guey Chuen Perng

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)


Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHFDSS. Lack of a suitable animal model for DHFDSS has hindered progress in defining the etiology of DHFDSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients.

Original languageEnglish
Pages (from-to)E24-E35
JournalAnnals of the New York Academy of Sciences
Issue numberSUPPL. 1
Publication statusPublished - 2009 Sep

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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