Abstract

Since large-scale reports of pulmonary infarction in systemic lupus erythematosus (SLE) are limited, a retrospective study was performed for this manifestation in 773 hospitalized patients in southern Taiwan from 1999 to 2009. Pulmonary infarction was defined as the presence of pulmonary embolism, persistent pulmonary infiltrates, and characteristic clinical symptoms. Demographic, clinical, laboratory, and radiological images data were analyzed. There were 12 patients with pulmonary embolism and 9 of them had antiphospholipid syndrome (APS). Six patients (19 to 53 years, average 38.2±12.6) with 9 episodes of lung infarction were identified. All cases were APS and four episodes had coincidental venous thromboembolism. There were four episodes of bilateral infarction and seven episodes of larger central pulmonary artery embolism. Heparin therapy was routinely prescribed and thrombolytic agents were added in two episodes. Successful recovery was noted in all patients. In conclusion, there was a 0.8% incidence of pulmonary infarction in patients with SLE, all with the risk factor of APS. Differentiation between pulmonary infarction and pneumonia in lupus patients should be made; they have similar chest radiography with lung consolidation but require a different clinical approach in management. Although this report is a retrospective study with relatively small numbers of lupus patients with lung infarcts, our observation might provide beneficial information on the clinical features and radiological presentations during the disease evolution of pulmonary infarction in SLE with APS.

Original languageEnglish
Pages (from-to)876-885
Number of pages10
JournalLupus
Volume20
Issue number8
DOIs
Publication statusPublished - 2011 Jul 1

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Pulmonary Infarction
Taiwan
Systemic Lupus Erythematosus
Retrospective Studies
Antiphospholipid Syndrome
Pulmonary Embolism
Lung
Infarction
Fibrinolytic Agents
Venous Thromboembolism
Radiography
Pulmonary Artery
Heparin
Pneumonia
Thorax
Observation
Demography
Incidence

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

@article{23a15cbdcfca491aafbe56de0aa0391e,
title = "A retrospective study of pulmonary infarction in patients with systemic lupus erythematosus from southern Taiwan",
abstract = "Since large-scale reports of pulmonary infarction in systemic lupus erythematosus (SLE) are limited, a retrospective study was performed for this manifestation in 773 hospitalized patients in southern Taiwan from 1999 to 2009. Pulmonary infarction was defined as the presence of pulmonary embolism, persistent pulmonary infiltrates, and characteristic clinical symptoms. Demographic, clinical, laboratory, and radiological images data were analyzed. There were 12 patients with pulmonary embolism and 9 of them had antiphospholipid syndrome (APS). Six patients (19 to 53 years, average 38.2±12.6) with 9 episodes of lung infarction were identified. All cases were APS and four episodes had coincidental venous thromboembolism. There were four episodes of bilateral infarction and seven episodes of larger central pulmonary artery embolism. Heparin therapy was routinely prescribed and thrombolytic agents were added in two episodes. Successful recovery was noted in all patients. In conclusion, there was a 0.8{\%} incidence of pulmonary infarction in patients with SLE, all with the risk factor of APS. Differentiation between pulmonary infarction and pneumonia in lupus patients should be made; they have similar chest radiography with lung consolidation but require a different clinical approach in management. Although this report is a retrospective study with relatively small numbers of lupus patients with lung infarcts, our observation might provide beneficial information on the clinical features and radiological presentations during the disease evolution of pulmonary infarction in SLE with APS.",
author = "Weng, {C. T.} and Chung, {T. J.} and Liu, {M. F.} and Weng, {M. Y.} and Lee, {C. H.} and Chen, {J. Y.} and Wu, {A. B.} and Lin, {B. W.} and Luo, {C. Y.} and Hsu, {S. C.} and Lee, {B. F.} and Tsai, {H. M.} and Chao, {S. C.} and Wang, {J. Y.} and Chen, {T. Y.} and Chen, {C. W.} and Chang, {H. Y.} and Wang, {C. R.}",
year = "2011",
month = "7",
day = "1",
doi = "10.1177/0961203311401458",
language = "English",
volume = "20",
pages = "876--885",
journal = "Lupus",
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T1 - A retrospective study of pulmonary infarction in patients with systemic lupus erythematosus from southern Taiwan

AU - Weng, C. T.

AU - Chung, T. J.

AU - Liu, M. F.

AU - Weng, M. Y.

AU - Lee, C. H.

AU - Chen, J. Y.

AU - Wu, A. B.

AU - Lin, B. W.

AU - Luo, C. Y.

AU - Hsu, S. C.

AU - Lee, B. F.

AU - Tsai, H. M.

AU - Chao, S. C.

AU - Wang, J. Y.

AU - Chen, T. Y.

AU - Chen, C. W.

AU - Chang, H. Y.

AU - Wang, C. R.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Since large-scale reports of pulmonary infarction in systemic lupus erythematosus (SLE) are limited, a retrospective study was performed for this manifestation in 773 hospitalized patients in southern Taiwan from 1999 to 2009. Pulmonary infarction was defined as the presence of pulmonary embolism, persistent pulmonary infiltrates, and characteristic clinical symptoms. Demographic, clinical, laboratory, and radiological images data were analyzed. There were 12 patients with pulmonary embolism and 9 of them had antiphospholipid syndrome (APS). Six patients (19 to 53 years, average 38.2±12.6) with 9 episodes of lung infarction were identified. All cases were APS and four episodes had coincidental venous thromboembolism. There were four episodes of bilateral infarction and seven episodes of larger central pulmonary artery embolism. Heparin therapy was routinely prescribed and thrombolytic agents were added in two episodes. Successful recovery was noted in all patients. In conclusion, there was a 0.8% incidence of pulmonary infarction in patients with SLE, all with the risk factor of APS. Differentiation between pulmonary infarction and pneumonia in lupus patients should be made; they have similar chest radiography with lung consolidation but require a different clinical approach in management. Although this report is a retrospective study with relatively small numbers of lupus patients with lung infarcts, our observation might provide beneficial information on the clinical features and radiological presentations during the disease evolution of pulmonary infarction in SLE with APS.

AB - Since large-scale reports of pulmonary infarction in systemic lupus erythematosus (SLE) are limited, a retrospective study was performed for this manifestation in 773 hospitalized patients in southern Taiwan from 1999 to 2009. Pulmonary infarction was defined as the presence of pulmonary embolism, persistent pulmonary infiltrates, and characteristic clinical symptoms. Demographic, clinical, laboratory, and radiological images data were analyzed. There were 12 patients with pulmonary embolism and 9 of them had antiphospholipid syndrome (APS). Six patients (19 to 53 years, average 38.2±12.6) with 9 episodes of lung infarction were identified. All cases were APS and four episodes had coincidental venous thromboembolism. There were four episodes of bilateral infarction and seven episodes of larger central pulmonary artery embolism. Heparin therapy was routinely prescribed and thrombolytic agents were added in two episodes. Successful recovery was noted in all patients. In conclusion, there was a 0.8% incidence of pulmonary infarction in patients with SLE, all with the risk factor of APS. Differentiation between pulmonary infarction and pneumonia in lupus patients should be made; they have similar chest radiography with lung consolidation but require a different clinical approach in management. Although this report is a retrospective study with relatively small numbers of lupus patients with lung infarcts, our observation might provide beneficial information on the clinical features and radiological presentations during the disease evolution of pulmonary infarction in SLE with APS.

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