A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery

Mei Chin Chen, Kiran Sonaje, Ko Jie Chen, Hsing Wen Sung

Research output: Contribution to journalReview articlepeer-review

283 Citations (Scopus)

Abstract

Success in the oral delivery of therapeutic insulin can significantly improve the quality of life of diabetic patients who must routinely receive injections of this drug. However, oral absorption of insulin is limited by various physiological barriers and remains a major scientific challenge. Various technological solutions have been developed to increase the oral bioavailability of insulin. Having received considerable attention, nano-sized polymeric particles are highly promising for oral insulin delivery. This review article describes the gastrointestinal barriers to oral insulin delivery, including chemical, enzymatic and absorption barriers. The potential transport mechanisms of insulin delivered by nanoparticles across the intestinal epithelium are also discussed. Finally, recent advances in using polymeric nanoparticles for oral insulin delivery and their effects on insulin transport are reviewed, along with their future.

Original languageEnglish
Pages (from-to)9826-9838
Number of pages13
JournalBiomaterials
Volume32
Issue number36
DOIs
Publication statusPublished - 2011 Dec 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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