A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research

Yufei Ren, Shun Ho Huang, Sébastien Mosser, Marc Olivier Heuschkel, Arnaud Bertsch, Patrick C. Fraering, Jia Jin Jason Chen, Philippe Renaud

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Polydimethylsiloxane (PDMS) and SU-8 are currently two very commonly used polymeric materials in the microfluidics field for biological applications. However, there is a pressing need to find a simple, reliable, irreversible bonding method between these two materials for their combined use in innovative integrated microsystems. In this paper, we attempt to investigate the aminosilane-mediated irreversible bonding method for PDMS and SU-8 with X-Ray Photoelectron Spectroscopy (XPS) surface analysis and bonding strength tests. Additionally, the selected bonding method was applied in fabricating a microelectrode array (MEA) device, including microfluidic features, which allows electrophysiological observations on compartmentalized neuronal cultures. As there is a growing trend towards microfluidic devices for neuroscience research, this type of integrated microdevice, which can observe functional alterations on compartmentalized neuronal culture, can potentially be used for neurodegenerative disease research and pharmaceutical development.

Original languageEnglish
Pages (from-to)1923-1934
Number of pages12
JournalMicromachines
Volume6
Issue number12
DOIs
Publication statusPublished - 2015 Jan 1

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Microelectrodes
Polydimethylsiloxane
Microfluidics
Neurodegenerative diseases
Microsystems
Surface analysis
Drug products
X ray photoelectron spectroscopy
Polymers

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Ren, Y., Huang, S. H., Mosser, S., Heuschkel, M. O., Bertsch, A., Fraering, P. C., ... Renaud, P. (2015). A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research. Micromachines, 6(12), 1923-1934. https://doi.org/10.3390/mi6121465
Ren, Yufei ; Huang, Shun Ho ; Mosser, Sébastien ; Heuschkel, Marc Olivier ; Bertsch, Arnaud ; Fraering, Patrick C. ; Chen, Jia Jin Jason ; Renaud, Philippe. / A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research. In: Micromachines. 2015 ; Vol. 6, No. 12. pp. 1923-1934.
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A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research. / Ren, Yufei; Huang, Shun Ho; Mosser, Sébastien; Heuschkel, Marc Olivier; Bertsch, Arnaud; Fraering, Patrick C.; Chen, Jia Jin Jason; Renaud, Philippe.

In: Micromachines, Vol. 6, No. 12, 01.01.2015, p. 1923-1934.

Research output: Contribution to journalArticle

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