A simple electrokinetic protein preconcentrator utilizing nano-interstices

Yu Hung Chen, Hsuan Franziska Wu, Tamara G. Amstislavskaya, Chang Yu Li, Chun Ping Jen

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


This work proposes a simple method for creating nanofluidic channels for protein preconcentration through self-assembled gold nanoparticles (AuNPs) using the exclusion-enrichment effect. A depletion force is elicited in nano-interstices among self-assembled AuNPs due to the overlap of electrical double layers (EDLs); therefore, proteins quickly accumulate. The experimental results show that the generation of depletion forces is correlated with the size of the AuNPs. The self-assembled monolayer of AuNPs (13 nm in diameter) can successfully preconcentrate proteins through effective EDL overlapping. This approach provides a new process to produce nanochannels that does not require high-voltage or time-consuming fabrication.

Original languageEnglish
Article number024121
Issue number2
Publication statusPublished - 2016 Mar 1

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Fluid Flow and Transfer Processes
  • Colloid and Surface Chemistry


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