A smart microfluidic-based fish farm for zebrafish screening

Karthick Mani, Chia Yuan Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Advances in microfluidics for zebrafish processing are critical to facilitate the bioassay in new drug development. Still, a manipulation platform for zebrafish relies mainly on the “static” agarose material and is coupled with the conventional fish facility to ensure the time-history investigation with the homogenous zebrafish population for drug screening. A fully automated IoT (Internet of Things) microfluidics system is necessary to be developed to enable smart and high-speed zebrafish testing without the need for fish facility support. In this work, a smart microfluidic device was presented to enable (i) highly efficient temperature control with the precision of ± 0.1 °C, (ii) remote zebrafish transport through light patterning, and (iii) perfusion and dynamic culturing of zebrafish all together assembled for on-chip high-quality imaging. A new microscale manipulation is envisaged to initiate a new chapter of running bioassays.

Original languageEnglish
Article number22
JournalMicrofluidics and Nanofluidics
Volume25
Issue number3
DOIs
Publication statusPublished - 2021 Mar

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

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