TY - JOUR
T1 - A suction-type, pneumatic microfluidic device for liquid transport and mixing
AU - Weng, Chen Hsun
AU - Lien, Kang Yi
AU - Yang, Sung Yi
AU - Lee, Gwo Bin
N1 - Funding Information:
Acknowledgments The authors gratefully acknowledge the financial support provided to this study by the National Science Council in Taiwan (NSC98-2627-B-006-006; NSC98-2120-M-006-001). This study is also partially supported by the Ministry of Education, Taiwan, ROC, under the NCKU Project for Promoting Academic Excellence & Developing World Class Research Centers.
PY - 2011/2
Y1 - 2011/2
N2 - This study presents a new suction-type, pneumatically driven microfluidic device for liquid delivery and mixing. The three major components, including two symmetrical, normally closed micro-valves and a sample transport/mixing unit, are integrated in this device. Liquid samples can be transported by the suction-type sample transport/mixing unit, which comprised a circular air chamber and a fluidic reservoir. Experimental results show that volume flow rates ranging from 50 to 300 μl/min can be precisely controlled during the sample transportation processes. Moreover, the transport/mixing unit can also be used as a micro-mixer to generate efficient mixing between two reaction chambers by regulating the time-phased deformation of the polydimethylsiloxane (PDMS) membranes. A mixing efficiency as high as 98.4% can be achieved within 5 s utilizing this prototype pneumatic microfluidic device. Consequently, the development of this new suction-type, pneumatic microfluidic device can be a promising tool for further biological applications and for chemical analysis when integrated into a micro-total analysis system (μ-TAS) device.
AB - This study presents a new suction-type, pneumatically driven microfluidic device for liquid delivery and mixing. The three major components, including two symmetrical, normally closed micro-valves and a sample transport/mixing unit, are integrated in this device. Liquid samples can be transported by the suction-type sample transport/mixing unit, which comprised a circular air chamber and a fluidic reservoir. Experimental results show that volume flow rates ranging from 50 to 300 μl/min can be precisely controlled during the sample transportation processes. Moreover, the transport/mixing unit can also be used as a micro-mixer to generate efficient mixing between two reaction chambers by regulating the time-phased deformation of the polydimethylsiloxane (PDMS) membranes. A mixing efficiency as high as 98.4% can be achieved within 5 s utilizing this prototype pneumatic microfluidic device. Consequently, the development of this new suction-type, pneumatic microfluidic device can be a promising tool for further biological applications and for chemical analysis when integrated into a micro-total analysis system (μ-TAS) device.
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U2 - 10.1007/s10404-010-0669-1
DO - 10.1007/s10404-010-0669-1
M3 - Article
AN - SCOPUS:79551490920
SN - 1613-4982
VL - 10
SP - 301
EP - 310
JO - Microfluidics and Nanofluidics
JF - Microfluidics and Nanofluidics
IS - 2
ER -