Abstract
As increase in collagen deposition is no longer taken as simply a consequence but, rather, an inducer of disease progression; therefore, the understanding of collagen signal transduction is fundamentally important. Cells contain at least two types of collagen receptors: integrins and discoidin domain receptors (DDRs). The integrin heterodimers α1β1, α2β1, α10β1, and α11β1 are recognized as the non-tyrosine kinase collagen receptors. DDR1 and 2, the tyrosine kinase receptors of collagen, are specifically expressed in epithelium and mesenchyme, respectively. While integrin β1 and DDR1 are both required for cell adhesion on collagen, their roles in epithelial cell differentiation during development and disease progression seem to counteract each other, with integrin β1 favoring epithelium mesenchyme transition (EMT) and DDR1 inducing epithelial cell differentiation. The in vitro evidence shows that the integrin β1 and DDR1 exert opposing actions in regulation of membrane stability of E-cadherin, which itself is a critical regulator of epithelial cell differentiation. Here, we review the functional roles of integrin β1 and DDR1 in regulation of epithelial cell differentiation during development and disease progression, and explore the underlining mechanisms regarding to the regulation of membrane stability of E-cadherin.
| Original language | English |
|---|---|
| Pages (from-to) | C1207-C1217 |
| Journal | American Journal of Physiology - Cell Physiology |
| Volume | 303 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2012 Dec 15 |
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All Science Journal Classification (ASJC) codes
- Physiology
- Cell Biology
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A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiation. / Yeh, Yi Chun; Lin, Hsi Hui; Tang, Ming Jer.
In: American Journal of Physiology - Cell Physiology, Vol. 303, No. 12, 15.12.2012, p. C1207-C1217.Research output: Contribution to journal › Review article
TY - JOUR
T1 - A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiation
AU - Yeh, Yi Chun
AU - Lin, Hsi Hui
AU - Tang, Ming Jer
PY - 2012/12/15
Y1 - 2012/12/15
N2 - As increase in collagen deposition is no longer taken as simply a consequence but, rather, an inducer of disease progression; therefore, the understanding of collagen signal transduction is fundamentally important. Cells contain at least two types of collagen receptors: integrins and discoidin domain receptors (DDRs). The integrin heterodimers α1β1, α2β1, α10β1, and α11β1 are recognized as the non-tyrosine kinase collagen receptors. DDR1 and 2, the tyrosine kinase receptors of collagen, are specifically expressed in epithelium and mesenchyme, respectively. While integrin β1 and DDR1 are both required for cell adhesion on collagen, their roles in epithelial cell differentiation during development and disease progression seem to counteract each other, with integrin β1 favoring epithelium mesenchyme transition (EMT) and DDR1 inducing epithelial cell differentiation. The in vitro evidence shows that the integrin β1 and DDR1 exert opposing actions in regulation of membrane stability of E-cadherin, which itself is a critical regulator of epithelial cell differentiation. Here, we review the functional roles of integrin β1 and DDR1 in regulation of epithelial cell differentiation during development and disease progression, and explore the underlining mechanisms regarding to the regulation of membrane stability of E-cadherin.
AB - As increase in collagen deposition is no longer taken as simply a consequence but, rather, an inducer of disease progression; therefore, the understanding of collagen signal transduction is fundamentally important. Cells contain at least two types of collagen receptors: integrins and discoidin domain receptors (DDRs). The integrin heterodimers α1β1, α2β1, α10β1, and α11β1 are recognized as the non-tyrosine kinase collagen receptors. DDR1 and 2, the tyrosine kinase receptors of collagen, are specifically expressed in epithelium and mesenchyme, respectively. While integrin β1 and DDR1 are both required for cell adhesion on collagen, their roles in epithelial cell differentiation during development and disease progression seem to counteract each other, with integrin β1 favoring epithelium mesenchyme transition (EMT) and DDR1 inducing epithelial cell differentiation. The in vitro evidence shows that the integrin β1 and DDR1 exert opposing actions in regulation of membrane stability of E-cadherin, which itself is a critical regulator of epithelial cell differentiation. Here, we review the functional roles of integrin β1 and DDR1 in regulation of epithelial cell differentiation during development and disease progression, and explore the underlining mechanisms regarding to the regulation of membrane stability of E-cadherin.
UR - http://www.scopus.com/inward/record.url?scp=84871260039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871260039&partnerID=8YFLogxK
U2 - 10.1152/ajpcell.00253.2012
DO - 10.1152/ajpcell.00253.2012
M3 - Review article
C2 - 23015544
AN - SCOPUS:84871260039
VL - 303
SP - C1207-C1217
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6143
IS - 12
ER -