A thiocyanate based molecular salt as an effective intercalator towards CT DNA

Bhaskar Biswas, Hui-Lien Tsai, Niranjan Kole

Research output: Contribution to journalArticle

Abstract

A previously reported thiocyanate based hybrid molecular salt l(dpaH)+(NCS)-] (1) (dpa = 2,2'-dipyridylamine) has been synthesized and structurally characterized. In this work, we have investigated the binding property of this salt with Calf Thymas DNA (CT DNA) using absorption and emission titration, thermal melting studies, viscosity experiments and circular dichroism studies. Binding curves constructed from absorption and emission changes indicate that, the molecular salt displays higher binding affinity (>105 M-1) towards DNA. Spectroscopic and hydrodynamic investigations reveal that molecular salt 1 behaves as an effective DNA intercalator.

Original languageEnglish
Pages (from-to)2101-2105
Number of pages5
JournalJournal of the Indian Chemical Society
Volume91
Issue number11
Publication statusPublished - 2014 Nov 1

Fingerprint

Intercalating Agents
calves
DNA
deoxyribonucleic acid
Salts
salts
Dichroism
Hydrodynamics
Circular Dichroism
Titration
Viscosity
titration
Freezing
dichroism
affinity
Melting
Hot Temperature
hydrodynamics
melting
viscosity

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Electrochemistry

Cite this

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A thiocyanate based molecular salt as an effective intercalator towards CT DNA. / Biswas, Bhaskar; Tsai, Hui-Lien; Kole, Niranjan.

In: Journal of the Indian Chemical Society, Vol. 91, No. 11, 01.11.2014, p. 2101-2105.

Research output: Contribution to journalArticle

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