A thiocyanate based molecular salt as an effective intercalator towards CT DNA

Bhaskar Biswas; Hui Lien Tsai; Niranjan Kole

A thiocyanate based molecular salt as an effective intercalator towards CT DNA

Bhaskar Biswas, Hui Lien Tsai, Niranjan Kole

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A previously reported thiocyanate based hybrid molecular salt l(dpaH)⁺(NCS)^-] (1) (dpa = 2,2'-dipyridylamine) has been synthesized and structurally characterized. In this work, we have investigated the binding property of this salt with Calf Thymas DNA (CT DNA) using absorption and emission titration, thermal melting studies, viscosity experiments and circular dichroism studies. Binding curves constructed from absorption and emission changes indicate that, the molecular salt displays higher binding affinity (>10⁵ M^-1) towards DNA. Spectroscopic and hydrodynamic investigations reveal that molecular salt 1 behaves as an effective DNA intercalator.

Original language	English
Pages (from-to)	2101-2105
Number of pages	5
Journal	Journal of the Indian Chemical Society
Volume	91
Issue number	11
Publication status	Published - 2014 Nov

All Science Journal Classification (ASJC) codes

Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Electrochemistry

Cite this

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abstract = "A previously reported thiocyanate based hybrid molecular salt l(dpaH)+(NCS)-] (1) (dpa = 2,2'-dipyridylamine) has been synthesized and structurally characterized. In this work, we have investigated the binding property of this salt with Calf Thymas DNA (CT DNA) using absorption and emission titration, thermal melting studies, viscosity experiments and circular dichroism studies. Binding curves constructed from absorption and emission changes indicate that, the molecular salt displays higher binding affinity (>105 M-1) towards DNA. Spectroscopic and hydrodynamic investigations reveal that molecular salt 1 behaves as an effective DNA intercalator.",

author = "Bhaskar Biswas and Tsai, {Hui Lien} and Niranjan Kole",

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AU - Tsai, Hui Lien

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N2 - A previously reported thiocyanate based hybrid molecular salt l(dpaH)+(NCS)-] (1) (dpa = 2,2'-dipyridylamine) has been synthesized and structurally characterized. In this work, we have investigated the binding property of this salt with Calf Thymas DNA (CT DNA) using absorption and emission titration, thermal melting studies, viscosity experiments and circular dichroism studies. Binding curves constructed from absorption and emission changes indicate that, the molecular salt displays higher binding affinity (>105 M-1) towards DNA. Spectroscopic and hydrodynamic investigations reveal that molecular salt 1 behaves as an effective DNA intercalator.

AB - A previously reported thiocyanate based hybrid molecular salt l(dpaH)+(NCS)-] (1) (dpa = 2,2'-dipyridylamine) has been synthesized and structurally characterized. In this work, we have investigated the binding property of this salt with Calf Thymas DNA (CT DNA) using absorption and emission titration, thermal melting studies, viscosity experiments and circular dichroism studies. Binding curves constructed from absorption and emission changes indicate that, the molecular salt displays higher binding affinity (>105 M-1) towards DNA. Spectroscopic and hydrodynamic investigations reveal that molecular salt 1 behaves as an effective DNA intercalator.

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A thiocyanate based molecular salt as an effective intercalator towards CT DNA

Abstract

All Science Journal Classification (ASJC) codes

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