A two-stage matched case-control study on multiple hypertensive candidate genes in han Chinese

Tai Yue Kuo, Mei Jyh Kang, Jaw Wen Chen, Hung Yun Ho, Chih Tai Ting, Tsung Hsien Lin, Sheng Hsiung Sheu, Wei Chuan Tsai, Jyh Hong Chen, Hsin Bang Leu, Wei Hsian Yin, Ting Yu Chiu, Chin Iuan Chen, Shing Jong Lin, Wen Harn Pan

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Abstract

Background Hypertension affects about 1/3 of adults worldwide, ∼3.8 million in Taiwan, 160 million in China, and 1 billion worldwide. It is a major risk factor leading to stroke, cardiovascular disease, and end-stage renal disease. In each year, more than 13.5 million deaths are due to hypertension-related diseases worldwide.MethodsWe performed a two-stage association study of hypertension using genotype data of single-nucleotide polymorphisms (SNPs) from 992 young-onset hypertensive cases and 992 matched controls of Han Chinese in Taiwan. A total of 238 SNPs of 36 highly replicated hypertension candidate genes with functional importance were investigated. Association analysis was carried out using conditional logistic regression.Results We identified two SNPs that were strongly associated with hypertension in both the first and the second stages. The first SNP (rs2301339) is located at guanine nucleotide-binding protein Β3 subunit (GNB3) and the other one (rs17254521) is located at insulin receptor (INSR).ConclusionsSNP rs2301339 is perfectly linked in linkage disequilibrium (LD) with C825T (rs5443) which has been associated with hypertension in Caucasian, but inconsistent in Asian populations. However, we found that in our sample this SNP has an opposite effect with the previous findings. In summary, this study identified one novel SNP in GNB3 and one novel SNP in INSR that are strongly associated with young-onset hypertension. Due to relatively small sample size, the Results should still be interpreted with caution and need to be replicated in other studies.

Original languageEnglish
Pages (from-to)804-811
Number of pages8
JournalAmerican Journal of Hypertension
Volume25
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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    Kuo, T. Y., Kang, M. J., Chen, J. W., Ho, H. Y., Ting, C. T., Lin, T. H., Sheu, S. H., Tsai, W. C., Chen, J. H., Leu, H. B., Yin, W. H., Chiu, T. Y., Chen, C. I., Lin, S. J., & Pan, W. H. (2012). A two-stage matched case-control study on multiple hypertensive candidate genes in han Chinese. American Journal of Hypertension, 25(7), 804-811. https://doi.org/10.1038/ajh.2012.44