A versatile approach to 6-substituted-5-methoxy-δ-lactam framework and application to the formal synthesis of (±)-homopumiliotoxin 223G

Bo Fong Chen, Min Ruei Tasi, Cheng Yu Yang, Jung Kai Chang, Nein Chen Chang

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Of the various 6-substituted-5-methoxy-δ-lactams 6 were synthesized from α-sulfonyl acetamide 9 in 4 steps in good yield. The key glutarimides 7 were obtained via facile [3+3] annulation. The method featured regioselective introduction of C-6 substituents in glutarimides 7. Synthesis of tribenzyl lactam 8 and the formal synthesis of (±)-homopumiliotoxin 223G were also reported. Graphical Abstract

Original languageEnglish
Pages (from-to)10223-10231
Number of pages9
JournalTetrahedron
Volume60
Issue number45
DOIs
Publication statusPublished - 2004 Nov 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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