Aberrant keratinization of reticular oral lichen planus is related to elastolysis

Shih Chung Liao, Po Chen Hsieh, Jehn-Shun Huang, Chia Wen Hsu, Kuo Yuan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective. Aberrant keratinization is common in oral lichen planus (OLP) on buccal mucosa. Because elastin is crucial for maintaining the nonkeratinized phenotype of oral mucosa, we examined whether inflammatory elastases and the accompanying elastolysis were related to this feature. Study Design. Protein and mRNA levels of keratinization-associated keratins (K1/10), nonkeratinization- associated keratins (K4/13), elastin, neutrophil elastase, and macrophage metalloelastase (MMP-12) were compared between normal alveolar mucosa and reticular OLP from buccal mucosa. Normal alveolar mucosae were cultured ex vivo on an organ culture system with and without elastase treatment. After 14 days, the mucosae were examined for 4 keratin expressions. Results. The expressions of K1/10 and elastases increased, whereas those of K4/13 and elastin decreased in OLP. The nonkeratinized mucosa in the organ culture began to express K1/10 when elastase degraded the inherent elastin. Conclusions. Our study demonstrated that elastolysis in reticular OLP may be related to its aberrant keratinization.

Original languageEnglish
Pages (from-to)808-816
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume113
Issue number6
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Oral Lichen Planus
Elastin
Pancreatic Elastase
Mouth Mucosa
Mucous Membrane
Organ Culture Techniques
Keratin-4
Keratin-13
Keratin-10
Matrix Metalloproteinase 12
Leukocyte Elastase
Matrix Metalloproteinases
Phenotype
Messenger RNA
Proteins

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

@article{f432289233d24b558a8e5571600f5203,
title = "Aberrant keratinization of reticular oral lichen planus is related to elastolysis",
abstract = "Objective. Aberrant keratinization is common in oral lichen planus (OLP) on buccal mucosa. Because elastin is crucial for maintaining the nonkeratinized phenotype of oral mucosa, we examined whether inflammatory elastases and the accompanying elastolysis were related to this feature. Study Design. Protein and mRNA levels of keratinization-associated keratins (K1/10), nonkeratinization- associated keratins (K4/13), elastin, neutrophil elastase, and macrophage metalloelastase (MMP-12) were compared between normal alveolar mucosa and reticular OLP from buccal mucosa. Normal alveolar mucosae were cultured ex vivo on an organ culture system with and without elastase treatment. After 14 days, the mucosae were examined for 4 keratin expressions. Results. The expressions of K1/10 and elastases increased, whereas those of K4/13 and elastin decreased in OLP. The nonkeratinized mucosa in the organ culture began to express K1/10 when elastase degraded the inherent elastin. Conclusions. Our study demonstrated that elastolysis in reticular OLP may be related to its aberrant keratinization.",
author = "Liao, {Shih Chung} and Hsieh, {Po Chen} and Jehn-Shun Huang and Hsu, {Chia Wen} and Kuo Yuan",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/j.oooo.2012.02.007",
language = "English",
volume = "113",
pages = "808--816",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "6",

}

Aberrant keratinization of reticular oral lichen planus is related to elastolysis. / Liao, Shih Chung; Hsieh, Po Chen; Huang, Jehn-Shun; Hsu, Chia Wen; Yuan, Kuo.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 113, No. 6, 01.01.2012, p. 808-816.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aberrant keratinization of reticular oral lichen planus is related to elastolysis

AU - Liao, Shih Chung

AU - Hsieh, Po Chen

AU - Huang, Jehn-Shun

AU - Hsu, Chia Wen

AU - Yuan, Kuo

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Objective. Aberrant keratinization is common in oral lichen planus (OLP) on buccal mucosa. Because elastin is crucial for maintaining the nonkeratinized phenotype of oral mucosa, we examined whether inflammatory elastases and the accompanying elastolysis were related to this feature. Study Design. Protein and mRNA levels of keratinization-associated keratins (K1/10), nonkeratinization- associated keratins (K4/13), elastin, neutrophil elastase, and macrophage metalloelastase (MMP-12) were compared between normal alveolar mucosa and reticular OLP from buccal mucosa. Normal alveolar mucosae were cultured ex vivo on an organ culture system with and without elastase treatment. After 14 days, the mucosae were examined for 4 keratin expressions. Results. The expressions of K1/10 and elastases increased, whereas those of K4/13 and elastin decreased in OLP. The nonkeratinized mucosa in the organ culture began to express K1/10 when elastase degraded the inherent elastin. Conclusions. Our study demonstrated that elastolysis in reticular OLP may be related to its aberrant keratinization.

AB - Objective. Aberrant keratinization is common in oral lichen planus (OLP) on buccal mucosa. Because elastin is crucial for maintaining the nonkeratinized phenotype of oral mucosa, we examined whether inflammatory elastases and the accompanying elastolysis were related to this feature. Study Design. Protein and mRNA levels of keratinization-associated keratins (K1/10), nonkeratinization- associated keratins (K4/13), elastin, neutrophil elastase, and macrophage metalloelastase (MMP-12) were compared between normal alveolar mucosa and reticular OLP from buccal mucosa. Normal alveolar mucosae were cultured ex vivo on an organ culture system with and without elastase treatment. After 14 days, the mucosae were examined for 4 keratin expressions. Results. The expressions of K1/10 and elastases increased, whereas those of K4/13 and elastin decreased in OLP. The nonkeratinized mucosa in the organ culture began to express K1/10 when elastase degraded the inherent elastin. Conclusions. Our study demonstrated that elastolysis in reticular OLP may be related to its aberrant keratinization.

UR - http://www.scopus.com/inward/record.url?scp=84862561537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862561537&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2012.02.007

DO - 10.1016/j.oooo.2012.02.007

M3 - Article

C2 - 22668709

AN - SCOPUS:84862561537

VL - 113

SP - 808

EP - 816

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 6

ER -