Ablation of promyelocytic leukemia protein (PML) re-patterns energy balance and protects mice from obesity induced by a western diet

Xiwen Cheng, Shuang Guo, Yu Liu, Hao Chu, Parvin Hakimi, Nathan A. Berger, Richard W. Hanson, Hung Ying Kao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, constitutive AMP-activating kinase (AMPK) activation, and insulin resistance in skeletal muscle. Last, an increased rate of energy expenditure protects PML KO mice from the effects of obesity induced by a Western diet. Collectively, our study uncovers a previously unappreciated role of PML in the regulation of metabolism and energy balance in mice.

Original languageEnglish
Pages (from-to)29746-29759
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number41
DOIs
Publication statusPublished - 2013 Oct 11

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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