Abnormalities of brain structure and density in schizophrenia

J. W. Largen, R. C. Smith, M. Calderon, R. Baumgartner, R. B. Lu, J. C. Schoolar, G. K. Ravichandran

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Quantitative and qualitative measures of brain morphology were derived through CT scans using computer-assisted methodology in patients with schizophrenia or schizo-affective psychosis and headache controls. Schizophrenics had significantly higher density of white matter, together with greater right vs. left asymmetry in density of white matter than controls. Schizophrenics tended to have larger widths of cortical sulci than headache patients. In our sample of schizophrenics, however, no significant differences were found on measures of lateral ventricle (LV) width, LV area, VBR, or other measures of ventricular size compared to headache controls. There were no differences between CT scan measures taken in patients with schizophrenia vs. schizo-affective psychosis.

Original languageEnglish
Pages (from-to)991-1013
Number of pages23
JournalBiological Psychiatry
Issue number7
Publication statusPublished - 1984 Nov 8

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry


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