Absence of CCR5-Δ32 mutation in healthy and HIV-1-infected aborigines in eastern Taiwan

Jaw Ming Cherng, Ji Hung Wang, Wen Lin Hsu, Kuo Liang Yang, Hsiao Yi Lin, Chrong-Reen Wang, Chi Mo Lin, Lih Shinn Wang

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Abstract

Objective: Human immunodeficiency virus type 1 requires coreceptor CCR5 to enter into host cells. Homozygous deletion of 32 nucleotides (CCR5-Δ32) of CCR5 results in a severely truncated molecule and near-complete protection against HIV-1 infection. This deletion mutation is commonly found in Caucasians. However, no such a mutation has yet been found in Hong Kong and Taiwan. Furthermore, most current data in Taiwan were collected from non-aborigines. Therefore, we investigated whether CCR5Δ32 mutation occurs in aborigines in eastern Taiwan. Materials and Methods: Genomic DNA was extracted from healthy aborigines (n=1433) and HIV-1 infected aboriginal patients (n=11) in eastern Taiwan. Genotyping was performed using polymerase chain reaction (PCR) amplification of a portion of the CCR5 gene and analyzed with agarose gel electrophoresis. Results: All samples contained the wild-type CCR5 gene structure and no single deleted form of the CCR5 gene was found. Conclusion: Although some Taiwan aborigines are believed to have European and other ancestors as well as mainland Chinese ancestors, Taiwan aborigines have a CCR5 gene construction similar to non-aboriginal Taiwanese.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalTzu Chi Medical Journal
Volume14
Issue number6
Publication statusPublished - 2002 Dec 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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